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Activation of R-mediated innate immunity and disease susceptibility is affected by mutations in a cytosolic O-acetylserine (thiol) lyase in Arabidopsis

文献类型：期刊论文

作者Tahir, Jibran; Watanabe, Mutsumi; Jing, Hai-Chun; Hunter, Donald A.; Tohge, Takayuki; Nunes-Nesi, Adriano; Brotman, Yariv; Fernie, Alisdair R.; Hoefgen, Rainer6; Dijkwel, Paul P.
刊名PLANT JOURNAL
出版日期2013
卷号73期号:1页码:118-130
关键词RPP1 OASTL-A1 disease resistance auto-necrosis cysteine biosynthesis innate immunity
ISSN号0960-7412
DOI10.1111/tpj.12021
文献子类Article
英文摘要O-acetylserine (thiol) lyases (OASTLs) are evolutionarily conserved proteins among many prokaryotes and eukaryotes that perform sulfur acquisition and synthesis of cysteine. A mutation in the cytosolic OASTL-A1 protein ONSET OF LEAF DEATH3 (OLD3) was previously shown to reduce the OASTL activity of the old3-1 protein in vitro and cause auto-necrosis in specific Arabidopsis accessions. Here we investigated why a mutation in this protein causes auto-necrosis in some but not other accessions. The auto-necrosis was found to depend on Recognition of Peronospora Parasitica 1 (RPP1)-like disease resistance R gene(s) from an evolutionarily divergent R gene cluster that is present in Ler-0 but not the reference accession Col-0. RPP1-like gene(s) show a negative epistatic interaction with the old3-1 mutation that is not linked to reduced cysteine biosynthesis. Metabolic profiling and transcriptional analysis further indicate that an effector triggered-like immune response and metabolic disorder are associated with auto-necrosis in old3-1 mutants, probably activated by an RPP1-like gene. However, the old3-1 protein in itself results in largely neutral changes in primary plant metabolism, stress defence and immune responses. Finally, we showed that lack of a functional OASTL-A1 results in enhanced disease susceptibility against infection with virulent and non-virulent Pseudomonas syringae pv. tomato DC3000 strains. These results reveal an interaction between the cytosolic OASTL and components of plant immunity.
学科主题Plant Sciences
出版地HOBOKEN
电子版国际标准刊号1365-313X
WOS关键词CYSTEINE SYNTHASE ; O-ACETYLSERINE(THIOL)LYASE GENE ; SERINE ACETYLTRANSFERASE ; FUNCTIONAL-ANALYSIS ; DEFENSE RESPONSES ; HYDROGEN-PEROXIDE ; BROAD-SPECTRUM ; HRP PILUS ; RESISTANCE ; METABOLISM
WOS研究方向Science Citation Index Expanded (SCI-EXPANDED)
语种英语
WOS记录号WOS:000314183300010
出版者WILEY
资助机构Higher Education Commission, Pakistan(Higher Education Commission of Pakistan) ; Massey University Research Fund ; Max Planck Society(Max Planck SocietyFoundation CELLEX)
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/28167]  
专题中科院北方资源植物重点实验室
作者单位1.[Watanabe, Mutsumi
2.Dijkwel, Paul P.] Massey Univ, Inst Mol BioSci, Palmerston North, New Zealand
3.[Hunter, Donald A.] New Zealand Inst Plant & Food Res Ltd, Palmerston North 4442, New Zealand
4.Chinese Acad Sci, Inst Bot, Ctr Bioenergy Plants Res & Dev, Beijing 100093, Peoples R China
5.Max Planck Inst Mol Pflanzenphysiol, D-14476 Potsdam, Germany
6.Fernie, Alisdair R.
7.Brotman, Yariv
8.Nunes-Nesi, Adriano
9.Tohge, Takayuki
10.[Tahir, Jibran
推荐引用方式
GB/T 7714		 Tahir, Jibran,Watanabe, Mutsumi,Jing, Hai-Chun,et al. Activation of R-mediated innate immunity and disease susceptibility is affected by mutations in a cytosolic O-acetylserine (thiol) lyase in Arabidopsis[J]. PLANT JOURNAL,2013,73(1):118-130.
APA Tahir, Jibran.,Watanabe, Mutsumi.,Jing, Hai-Chun.,Hunter, Donald A..,Tohge, Takayuki.,...&Dijkwel, Paul P..(2013).Activation of R-mediated innate immunity and disease susceptibility is affected by mutations in a cytosolic O-acetylserine (thiol) lyase in Arabidopsis.PLANT JOURNAL,73(1),118-130.
MLA Tahir, Jibran,et al."Activation of R-mediated innate immunity and disease susceptibility is affected by mutations in a cytosolic O-acetylserine (thiol) lyase in Arabidopsis".PLANT JOURNAL 73.1(2013):118-130.

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来源：植物研究所

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