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Potentiometric sensor based on a computationally designed molecularly imprinted receptor

文献类型：期刊论文

作者Cui, Guohua3; Liang, Rongning3; Qin, Wei1,2,3
刊名ANALYTICA CHIMICA ACTA
出版日期2023-01-25
卷号1239页码:9
关键词Potentiometry Ion -selective electrode Molecularly imprinted polymer Computer -aided design Sulfadiazine
ISSN号0003-2670
DOI10.1016/j.aca.2022.340720
通讯作者Liang, Rongning(rnliang@yic.ac.cn) ; Qin, Wei(wqin@yic.ac.cn)
英文摘要Molecularly imprinted polymer (MIP)-based polymeric membrane potentiometric sensors are ideal candidates for detection of organic species. The development of such sensors has opened new attractive horizons for potentiometric sensing. However, it should be noted that in the preparation of these MIP receptors, the selection of the functional monomer usually depends on empirical trial-and error-based optimization, which involves tedious and time-consuming experiments. In this work, the computer-aided design and synthesis of an MIP re-ceptor are applied in the fabrication of an MIP-based potentiometric sensor. The density functional theory calculation with the B3LYP model and 6-31G(d) basis set is used to study the interactions between the functional monomer and template molecules. The binding energies of the complexations between the template molecule and different functional monomers are used as a criterion for the selection of the proper monomer. The designed MIP is then synthesized and employed as the receptor for the fabrication of the potentiometric sensor. As a proof -of-concept experiment, the antibiotic sulfadiazine has been selected as a model and 4 functional monomers, 2-hydroxyethyl methacrylate, methyl methacrylate, N-isopropylacrylamide and N-phenylacrylamide, have been chosen. The designed MIP-based sensor exhibits excellent sensitivity with a linear range of 1-10 mu M and also shows a good selectivity. We believe that the proposed computer-aided synthesis technique for the MIP receptor selection can provide a general and facile way to replace the traditional empirical MIP preparation method in the fabrication of MIP-based electrochemical and optical sensors.
WOS关键词ION-SELECTIVE ELECTRODES ; POLYMER
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000904960100009
资助机构National Natural Science Foundation of China ; Key Deployment Project of Centre for Ocean Mega -Research of Science, Chinese Academy of Sciences ; Youth Innovation Promotion Association of CAS ; Taishan Scholar Program of Shandong Province
源URL[http://ir.yic.ac.cn/handle/133337/32476]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_近岸生态与环境实验室
通讯作者Liang, Rongning; Qin, Wei
作者单位1.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Cui, Guohua,Liang, Rongning,Qin, Wei. Potentiometric sensor based on a computationally designed molecularly imprinted receptor[J]. ANALYTICA CHIMICA ACTA,2023,1239:9.
APA Cui, Guohua,Liang, Rongning,&Qin, Wei.(2023).Potentiometric sensor based on a computationally designed molecularly imprinted receptor.ANALYTICA CHIMICA ACTA,1239,9.
MLA Cui, Guohua,et al."Potentiometric sensor based on a computationally designed molecularly imprinted receptor".ANALYTICA CHIMICA ACTA 1239(2023):9.

入库方式： OAI收割

来源：烟台海岸带研究所

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