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Time- and dose-dependent detoxification and reproductive endocrine disruption induced by tetrabromobisphenol A (TBBPA) in mussel Mytilus galloprovincialis

文献类型：期刊论文

作者Wang, Shuang3,4,5; Sun, Zuodeng1; Ren, Chuanbo2; Li, Fei5; Xu, Yingjiang2; Wu, Huifeng5; Ji, Chenglong5
刊名MARINE ENVIRONMENTAL RESEARCH
出版日期2023
卷号183页码:10
ISSN号0141-1136
关键词Tetrabromobisphenol A Detoxification Reproductive endocrine disruption Sulfation Mytilus galloprovincialis
DOI10.1016/j.marenvres.2022.105839
通讯作者Ji, Chenglong(clji@yic.ac.cn)
英文摘要As a typical brominated flame retardant (BFR), tetrabromobisphenol A (TBBPA) has been frequently detected in both biotic and abiotic matrices in marine environment. Our previous study found that genes related to metabolism phase I/II/III as well as steroid metabolism in Mytilus galloprovincialis were significantly altered by TBBPA treatment. However, the time- and dose-dependent response profiles of these genes to TBBPA exposure were rarely reported. In this study, the time- and dose-dependent effects of TBBPA on detoxification and reproductive endocrine disruption in M. galloprovincialis were explored by evaluating the responses of related gene expressions, enzymatic activities and gametogenesis to different concentrations of TBBPA (0.6, 3, 15, 75 and 375 mu g/L) for different durations (14, 21 and 28 days). The results showed that the TBBPA accumulation increased linearly with the increases of exposure time and dose. Cytochrome P450 family 3 (CYP3A1-like) cooperated with CYP4Y1 for phase I biotransformation of TBBPA in mussels. The dose-response curves of phase II/III genes (glutathione-Stransferase (GST), P-glycoprotein (ABCB), and multidrug resistance protein (ABCC)) showed similar response profiles to TBBPA exposure. The common induction of phase I/II/III (CYPs, GST, ABCB and ABCC) suggested TBBPA detoxification regulation in mussels probably occurred in a step-wise manner. Concurrently, direct sulfation mediated by sulfotransferases (SULTs) on TBBPA was also the vital metabolic mechanism for TBBPA detoxification, which was supported by the coincidence between up-regulation of SULT1B1 and TBBPA accumulation. The significant promotion of steroid sulfatase (STS) might result from TBBPA-sulfate catalyzed by SULT1B1 due to its chemical similarity to estrone-sulfate. Furthermore, the promotion of gametogenesis was consistent with the induction of STS, suggesting that STS might interrupt steroids hydrolysis process and was responsible for reproductive endocrine disruption in M. galloprovincialis. This study provides a better understanding of the detoxification and endocrine-disrupting mechanisms of TBBPA.
WOS关键词BROMINATED FLAME RETARDANTS ; OXIDATIVE STRESS ; GENE-EXPRESSION ; BIOTRANSFORMATION ; METABOLISM ; RESPONSES ; EXPOSURE ; TISSUE ; BIOACCUMULATION ; ANTIOXIDANT
WOS研究方向Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Toxicology
语种英语
WOS记录号WOS:000911308900003
资助机构National Natural Science Foundation of China ; Yantai Science and Technology Development Plan
源URL[http://ir.yic.ac.cn/handle/133337/32543]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_近岸生态与环境实验室
通讯作者Ji, Chenglong
作者单位1.Shandong Fisheries Dev & Resource Conservat Ctr, Jinan 250013, Peoples R China
2.Shandong Marine Resource & Environm Res Inst, Yantai 264006, Peoples R China
3.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, YICCAS,CAS Key Lab Coastal Environm Proc & Ecol Re, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Shuang,Sun, Zuodeng,Ren, Chuanbo,et al. Time- and dose-dependent detoxification and reproductive endocrine disruption induced by tetrabromobisphenol A (TBBPA) in mussel Mytilus galloprovincialis[J]. MARINE ENVIRONMENTAL RESEARCH,2023,183:10.
APA Wang, Shuang.,Sun, Zuodeng.,Ren, Chuanbo.,Li, Fei.,Xu, Yingjiang.,...&Ji, Chenglong.(2023).Time- and dose-dependent detoxification and reproductive endocrine disruption induced by tetrabromobisphenol A (TBBPA) in mussel Mytilus galloprovincialis.MARINE ENVIRONMENTAL RESEARCH,183,10.
MLA Wang, Shuang,et al."Time- and dose-dependent detoxification and reproductive endocrine disruption induced by tetrabromobisphenol A (TBBPA) in mussel Mytilus galloprovincialis".MARINE ENVIRONMENTAL RESEARCH 183(2023):10.

入库方式： OAI收割

来源：烟台海岸带研究所

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