Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut-Liver Axis in Diet-Induced High-Fat Mesocricetus auratus through Multiple Integrated Omics
文献类型：期刊论文
| 作者 | Zeng, Hongliang2,3,4; Chen, Peilin3,4; Wang, Zhiyun3,4; Hu, Xiaoke1 ; Zhang, Yi2,3,4; Zheng, Baodong2,3,4
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| 刊名 | MOLECULAR NUTRITION & FOOD RESEARCH
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| 出版日期 | 2023-01-26 |
| 页码 | 15 |
| ISSN号 | 1613-4125 |
| 关键词 | gut microbiota gut-liver axis hyperlipidemia lipomics Porphyra haitanensis polysaccharide transcriptomics |
| DOI | 10.1002/mnfr.202200638 |
| 通讯作者 | Zhang, Yi(zyifst@fafu.edu.cn) ; Zheng, Baodong(zbdfst@fafu.edu.cn) |
| 英文摘要 | ScopeHyperlipidemia is currently a global public health problem severely affecting people's physical and mental health, as well as their quality of life. Methods and resultsThe present study is aimed at revealing the mechanism of Porphyra haitanensis polysaccharide (PHP) in decreasing blood lipids by acting through gut-liver axis in Mesocricetus auratus fed a high-fat diet. PHP significantly prevented increases in serum total cholesterol, triglycerides and low-density lipoprotein cholesterol, and alleviated damage to liver cells induced by a high-fat diet M. auratus, in a dose-dependent manner. PHP promotes proliferation of Muribaculaceae and Faecalibaculum, thereby enhancing the production of butyric acid both in the colon and liver, particularly high-dose PHP (HPHP). Low-dose PHP (LPHP) promotes the expression of phosphatidylcholine metabolites and fatty acid transport genes, and inhibits the expression of genes involved in fat degradation (Abhd5), adipogenesis (Me1), fatty acid synthesis (Fasn and Pnpla3), and fatty acid chain elongation (Elovl6) in the liver. However, HPHP inhibits the expression of triglyceride metabolites and promotes the expression of fatty acid transporter (CD36), fatty acid oxidation (Acacb), and peroxisome proliferator-activated receptor gamma (PPARg) genes in the liver. ConclusionPHP regulates lipid metabolism through the gut microbiota, and the gut-liver axis plays an important role in its hypolipidemic effects. |
| WOS关键词 | LIPOPROTEIN-LIPASE ; IN-VITRO ; SULFATED POLYSACCHARIDE ; HEPATIC STEATOSIS ; ADIPOSE-TISSUE ; PPAR-GAMMA ; MICROBIOTA ; OBESITY ; VIVO ; ANTIOXIDANT |
| WOS研究方向 | Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000918971400001 |
| 资助机构 | Program for Leading Talent in Fujian Provincial University |
| 源URL | [http://ir.yic.ac.cn/handle/133337/32083]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 通讯作者 | Zhang, Yi; Zheng, Baodong |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Fujian Agr & Forestry Univ, Fujian Prov Key Lab Qual Sci & Proc Technol Specia, Fuzhou 350002, Peoples R China 3.Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China 4.Minist Educ, Engn Res Ctr Fujian Taiwan Special Marine Food Pro, Fuzhou 350002, Fujian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Hongliang,Chen, Peilin,Wang, Zhiyun,et al. Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut-Liver Axis in Diet-Induced High-Fat Mesocricetus auratus through Multiple Integrated Omics[J]. MOLECULAR NUTRITION & FOOD RESEARCH,2023:15. |
| APA | Zeng, Hongliang,Chen, Peilin,Wang, Zhiyun,Hu, Xiaoke,Zhang, Yi,&Zheng, Baodong.(2023).Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut-Liver Axis in Diet-Induced High-Fat Mesocricetus auratus through Multiple Integrated Omics.MOLECULAR NUTRITION & FOOD RESEARCH,15. |
| MLA | Zeng, Hongliang,et al."Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut-Liver Axis in Diet-Induced High-Fat Mesocricetus auratus through Multiple Integrated Omics".MOLECULAR NUTRITION & FOOD RESEARCH (2023):15. |
入库方式： OAI收割
来源：烟台海岸带研究所
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