The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis In Vitro
文献类型：期刊论文
| 作者 | Liu, Run-Ze2,3; Li, Wen-Jun2,3 ; Zhang, Juan-Juan1; Liu, Zheng-Yi2,3; Li, Ya1; Liu, Chao1; Qin, Song2,3
|
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2022-11-01 |
| 卷号 | 20期号:11页码:20 |
| 关键词 | phycocyanin phycocyanin peptide pulmonary fibrosis inflammatory oxidative stress heme oxygenases-1 |
| DOI | 10.3390/md20110696 |
| 通讯作者 | Liu, Chao(sanmu_363@163.com) ; Qin, Song(sqin@yic.ac.cn) |
| 英文摘要 | Phycocyanin is an excellent antioxidant with anti-inflammatory effects on which recent studies are growing; however, its specific target remains unclear. Linear tetrapyrrole compounds such as bilirubin have been shown to lead to the induction of heme oxygenase 1 expression in vivo, thus achieving antioxidant and anti-inflammatory effects. Phycocyanin is bound internally with linear tetrapyrrole phycocyanobilin in a similar structure to bilirubin. We speculate that there is probably a way of inducing the expression of heme oxygenase 1, with which tissue oxidative stress and inflammation can be inhibited, thus inhibiting pulmonary fibrosis caused by oxidative damage and inflammation of lung. By optimizing the enzymatic hydrolysis process, phycocyanobilin-bound phycocyanin peptide were obtained, and its in vitro antioxidant, anti-inflammatory, and anti-pulmonary fibrosis activities were investigated. The results show that the phycocyanobilin peptide was able to alleviate oxidative and inflammatory damage in cells through the Keap1-Nrf2-HO-1 pathway, which in turn relieved pulmonary fibrosis symptoms. |
| WOS关键词 | HEME OXYGENASE-1 ; RAW264.7 MACROPHAGES ; PROVIDES PROTECTION ; PROTEIN HYDROLYSATE ; C-PHYCOCYANIN ; ACTIVATION ; ANTIOXIDANT ; INFLAMMATION ; CYTOKINES ; OXIDATION |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000883497200001 |
| 资助机构 | National key research and development program of China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/32398]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 通讯作者 | Liu, Chao; Qin, Song |
| 作者单位 | 1.Yantai Jiahui Biotech Co Ltd, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Run-Ze,Li, Wen-Jun,Zhang, Juan-Juan,et al. The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis In Vitro[J]. MARINE DRUGS,2022,20(11):20. |
| APA | Liu, Run-Ze.,Li, Wen-Jun.,Zhang, Juan-Juan.,Liu, Zheng-Yi.,Li, Ya.,...&Qin, Song.(2022).The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis In Vitro.MARINE DRUGS,20(11),20. |
| MLA | Liu, Run-Ze,et al."The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis In Vitro".MARINE DRUGS 20.11(2022):20. |
入库方式： OAI收割
来源：烟台海岸带研究所
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