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Identification of Key Genes as Potential Drug Targets for Gastric Cancer

文献类型：期刊论文

作者Hossain, Md. Tofazzal2,3,4; Reza, Md. Selim4; Peng, Yin1; Feng, Shengzhong4; Wei, Yanjie4
刊名TSINGHUA SCIENCE AND TECHNOLOGY
出版日期2023-08-01
卷号28期号:4页码:649-664
关键词gastric cancer hub genes candidate genes molecular docking candidate drugs
ISSN号1007-0214
DOI10.26599/TST.2022.9010035
英文摘要Gastric cancer (GC) is one of the most common cancers and ranks the third in cancer mortality all over the world. The goal of this study was to identify potential hub-genes, highlighting their functions, signaling pathways, and candidate drugs for the treatment of GC patients. We used publicly available next generation sequencing (NGS) data to identify differentially expressed (DE) genes. The top DE genes were mapped to STRING database to construct the protein-protein interaction (PPI) network and top hub genes were selected for further analysis. We found a total of 1555 DE genes with 870 upregulated and 685 downregulated genes in GC. We selected the top 400 (200 upregulated and 200 downregulated) genes to construct a PPI network and extracted the top 15 hub genes. The gene ontology (GO) term and kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analyses of the 15 hub genes exposed some important functions and signaling pathways that were significantly associated with GC patients. The survival analysis of the hub genes disclosed that the lower expressions of the three hub genes CDH2, COL4A1, and COL5A2 were associated with better survival of GC patients. These three genes might be the candidate biomarkers for the diagnosis and treatment of GC. Then, we considered 3 key proteins (genomic biomarkers) (COL4A1, CDH2, and CO5A2) as the drug target proteins (receptors), performed their docking analysis with the 102 meta-drug agents, and found Everolimus, Docetaxel, Lanreotide, Venetoclax, Temsirolimus, and Nilotinib as the top ranked 6 candidate drugs with respect to our proposed target proteins for the treatment against GC patients. Therefore, the proposed drugs might play vital role for the treatment against GC patients.
资助项目National Key Research and Development Program of China[2018YFB0204403] ; Key Research and Development Project of Guangdong Province[2021B0101310002] ; Strategic Priority CAS Project[XDB38050100] ; National Science Foundation of China[U1813203] ; Shenzhen Basic Research Fund[RCYX2020071411473419] ; Shenzhen Basic Research Fund[KQTD20200820113106007] ; Shenzhen Basic Research Fund[JSGG20201102163800001] ; CAS Key Lab[2011DP173015] ; Youth Innovation Promotion Association[Y2021101]
WOS研究方向Computer Science ; Engineering
语种英语
WOS记录号WOS:000923065700004
出版者TSINGHUA UNIV PRESS
源URL[http://119.78.100.204/handle/2XEOYT63/19932]  
专题中国科学院计算技术研究所期刊论文
通讯作者Wei, Yanjie
作者单位1.Shenzhen Univ, Dept Pathol, Guangdong Prov Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China
2.Bangabandhu Sheikh Mujibur Rahman Sci & Technol Un, Dept Stat, Gopalganj 8100, Bangladesh
3.Univ Chinese Acad Sci, Sch Comp Sci & Technol, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr High Performance Comp, Joint Engn Res Ctr Hlth Big Data Intelligent Anal, Shenzhen 518055, Peoples R China
推荐引用方式
GB/T 7714		 Hossain, Md. Tofazzal,Reza, Md. Selim,Peng, Yin,et al. Identification of Key Genes as Potential Drug Targets for Gastric Cancer[J]. TSINGHUA SCIENCE AND TECHNOLOGY,2023,28(4):649-664.
APA Hossain, Md. Tofazzal,Reza, Md. Selim,Peng, Yin,Feng, Shengzhong,&Wei, Yanjie.(2023).Identification of Key Genes as Potential Drug Targets for Gastric Cancer.TSINGHUA SCIENCE AND TECHNOLOGY,28(4),649-664.
MLA Hossain, Md. Tofazzal,et al."Identification of Key Genes as Potential Drug Targets for Gastric Cancer".TSINGHUA SCIENCE AND TECHNOLOGY 28.4(2023):649-664.

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