Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation
文献类型：期刊论文
| 作者 | Yang, Zhen5; Xu, Feng5; Teschendorff, Andrew E.4; Zhao, Yi3; Yao, Lei2; Li, Jian5; He, Yungang1,5 |
| 刊名 | FRONTIERS IN MOLECULAR BIOSCIENCES
 |
| 出版日期 | 2022-12-02 |
| 卷号 | 9页码:23 |
| 关键词 | lncRNA circRNA DNA methylation histone modification transcriptional regulation regulatory network |
| DOI | 10.3389/fmolb.2022.1067406 |
| 英文摘要 | DNA methylation is one of the most important epigenetic mechanisms that governing regulation of gene expression, aberrant DNA methylation patterns are strongly associated with human malignancies. Long non-coding RNAs (lncRNAs) have being discovered as a significant regulator on gene expression at the epigenetic level. Emerging evidences have indicated the intricate regulatory effects between lncRNAs and DNA methylation. On one hand, transcription of lncRNAs are controlled by the promoter methylation, which is similar to protein coding genes, on the other hand, lncRNA could interact with enzymes involved in DNA methylation to affect the methylation pattern of downstream genes, thus regulating their expression. In addition, circular RNAs (circRNAs) being an important class of noncoding RNA are also found to participate in this complex regulatory network. In this review, we summarize recent research progress on this crosstalk between lncRNA, circRNA, and DNA methylation as well as their potential functions in complex diseases including cancer. This work reveals a hidden layer for gene transcriptional regulation and enhances our understanding for epigenetics regarding detailed mechanisms on lncRNA regulatory function in human cancers. |
| 资助项目 | National Natural Science Foundation of China ; Shanghai Municipal Science and Technology ; Project of Science and Technology Department of Sichuan Provincial of China ; [91959106] ; [31871255] ; [2017SHZDZX01] ; [2019JDJQ0035] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000898774900001 |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/20219]  |
| 专题 | 中国科学院计算技术研究所期刊论文 |
| 通讯作者 | Yang, Zhen |
| 作者单位 | 1.Fudan Univ, Shanghai Peoples Hosp 5, Shanghai, Peoples R China 2.Southwest Med Univ, Affiliated Hosp, Expt Med Ctr, Luzhou, Sichuan, Peoples R China 3.Chinese Acad Sci, Inst Comp Technol, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Computat Biol, Shanghai, Peoples R China 5.Fudan Univ, Pudong Hosp, Ctr Med Res & Innovat, Inst Biomed Sci,Shanghai Key Lab Med Epigenet,Int, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Zhen,Xu, Feng,Teschendorff, Andrew E.,et al. Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2022,9:23. |
| APA | Yang, Zhen.,Xu, Feng.,Teschendorff, Andrew E..,Zhao, Yi.,Yao, Lei.,...&He, Yungang.(2022).Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation.FRONTIERS IN MOLECULAR BIOSCIENCES,9,23. |
| MLA | Yang, Zhen,et al."Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation".FRONTIERS IN MOLECULAR BIOSCIENCES 9(2022):23. |
入库方式： OAI收割
来源：计算技术研究所
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