The impact of pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities in young adults
文献类型:期刊论文
作者 | Mengge Liu8; Tong Han9; Yue Wu10; Jingliang Cheng4; Longjiang Zhang11; Bing Zhang12; Xi-Nian Zuo13,14; Wenzhen Zhu15; Shijun Qiu16; Zuojun Geng17 |
刊名 | Environment International |
出版日期 | 2023 |
通讯作者邮箱 | ouwenliao@163.com (w.-h. liao) ; daweiwangtj@126.com (d. wang) ; chunshuiyu@tmu.edu.cn (c. yu) |
关键词 | Hippocampal subfields Urban Neurocognition Remote sensing Neuroimaging |
DOI | 10.1016/j.envint.2023.107905 |
文献子类 | 实证研究 |
英文摘要 | BACKGROUND: Urbanicity refers to the conditions that are particular to urban areas and is a growing environmental challenge that may affect hippocampus and neurocognition. This study aimed to investigate the effects of the average pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities as well as the sensitive age windows of the urbanicity effects. PARTICIPANTS AND METHODS: We included 5,390 CHIMGEN participants (3,538 females; age: 23.69±2.26years, range: 18-30years). Pre-adulthood urbanicity of each participant was defined as the average value of annual night-time light (NL) or built-up% from age 0-18, which were extracted from remote-sensing satellite data based on annual residential coordinates of the participants. The hippocampal subfield volumes were calculated based on structural MRI and eight neurocognitive measures were assessed. The linear regression was applied to investigate the associations of pre-adulthood NL with hippocampal subfield volumes and neurocognitive abilities, mediation models were used to find the underlying pathways among urbanicity, hippocampus and neurocognition, and distributed lag models were used to identify sensitive age windows of urbanicity effect. RESULTS: Higher pre-adulthood NL was associated with greater volumes in the left (beta=0.100, 95%CI: [0.075, 0.125]) and right (0.078, [0.052, 0.103]) fimbria and left subiculum body (0.045, [0.020, 0.070]) and better neurocognitive abilities in information processing speed (-0.212, [-0.240, -0.183]), working memory (0.085, [0.057, 0.114]), episodic memory (0.107, [0.080, 0.135]), and immediate (0.094, [0.065, 0.123]) and delayed (0.087, [0.058, 0.116]) visuospatial recall, and hippocampal subfield volumes and visuospatial memory showed bilateral mediations for the urbanicity effects. Urbanicity effects were greatest on the fimbria in preschool and adolescence, on visuospatial memory and information processing from childhood to adolescence and on working memory after 14years. CONCLUSION: These findings improve our understanding of the impact of urbanicity on hippocampus and neurocognitive abilities and will benefit for designing more targeted intervention for neurocognitive improvement. |
收录类别 | SCI |
源URL | [http://ir.psych.ac.cn/handle/311026/44827] |
专题 | 中国科学院心理研究所 |
作者单位 | 1.Department of Radiology, Xiangya Hospital, Central South University, 410008 Changsha, China 2.Ministry of Education Key Laboratory for Earth System Modeling, Department of Earth System Science, Tsinghua University, Beijing, China 3.Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, 221006 Xuzhou, China 4.Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, China 5.Molecular Imaging Research Center of Central South University, 410008 Changsha, China 6.National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008 Changsha, China 7.Department of Radiology, Qilu Hospital of Shandong University, 250012 Jinan, China 8.The impact of pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities in young adults 9.Department of Radiology, Tianjin Huanhu Hospital, 300350 Tianjin, China 10.Department of Radiology, Huashan Hospital, Fudan University, 200040 Shanghai, China |
推荐引用方式 GB/T 7714 | Mengge Liu,Tong Han,Yue Wu,et al. The impact of pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities in young adults[J]. Environment International,2023. |
APA | Mengge Liu.,Tong Han.,Yue Wu.,Jingliang Cheng.,Longjiang Zhang.,...&Chunshui Yu.(2023).The impact of pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities in young adults.Environment International. |
MLA | Mengge Liu,et al."The impact of pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities in young adults".Environment International (2023). |
入库方式: OAI收割
来源:心理研究所
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