One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4H-chromenes: Discovery of a Type of Potent Antibacterial Agent
文献类型：期刊论文
| 作者 | Zhang G(张根)1; Zhang YH(张耀虎)1; Yan JX(闫洁熙)1; Chen R(陈茹)1; Wang SL(王守磊)1; Ma YX(马赟霞)1; Wang R(王锐)1,2 |
| 刊名 | the Journal of Organic Chemistry
 |
| 出版日期 | 2012 |
| 卷号 | 77期号:2页码:878-888 |
| ISSN号 | 0022-3263 |
| 通讯作者 | 王锐 |
| 英文摘要 | Function-oriented design and synthesis of chiral small molecules with novel activity is a key goal in modern organic chemistry. As multiple antibiotic-resistant pathogens are emerging and causing serious diseases, the need for practical routes for the development of new types of antibacterial agents is very urgent. Herein, we present a highly efficient process for the synthesis of optically active pyranocoumarins and 2-amino-4H-chromenes through an organocatalytic Knoevenagel/Michael/cyclization sequence, and the preliminary biological studies of these new heterocyclic compounds revealed potent antibacterial activity. This study provides a novel strategy for further research and development of new types of antibacterial agents effective against human pathogens. |
| 学科主题 | 物理化学与绿色催化 |
| 收录类别 | SCI |
| 资助信息 | the National Natural Science Foundation of China (No. 90813012;20932003);the Key National S & T Program “Major New Drug Development” of the Ministry of Science and Technology (2012ZX09504001-003) |
| 语种 | 英语 |
| WOS记录号 | WOS:000299238400007 |
| 公开日期 | 2013-10-11 |
| 源URL | [http://210.77.64.217/handle/362003/3836]  |
| 专题 | 兰州化学物理研究所_OSSO国家重点实验室 |
| 作者单位 | 1.Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Inst Biochem & Mol Biol, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang G,Zhang YH,Yan JX,et al. One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4H-chromenes: Discovery of a Type of Potent Antibacterial Agent[J]. the Journal of Organic Chemistry,2012,77(2):878-888. |
| APA | Zhang G.,Zhang YH.,Yan JX.,Chen R.,Wang SL.,...&Wang R.(2012).One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4H-chromenes: Discovery of a Type of Potent Antibacterial Agent.the Journal of Organic Chemistry,77(2),878-888. |
| MLA | Zhang G,et al."One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4H-chromenes: Discovery of a Type of Potent Antibacterial Agent".the Journal of Organic Chemistry 77.2(2012):878-888. |
入库方式： OAI收割
来源：兰州化学物理研究所
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