Stereoselective synthesis of trans beta-lactams via palladium/N-heterocyclic carbene-catalyzed carbonylative [2+2] cycloaddition
文献类型：期刊论文
| 作者 | Jie P(解攀) ; Qian B(钱波); Huang HM(黄汉民); Xia CG(夏春谷)
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| 刊名 | Tetrahedron Letters
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| 出版日期 | 2012 |
| 卷号 | 53期号:13页码:1613-1616 |
| 关键词 | trans-beta-Lactam N-heterocyclic carbene Palladium Carbonylative [2+2] Cycloaddition |
| ISSN号 | 0040-4039 |
| 通讯作者 | 黄汉民 ; 夏春谷 |
| 英文摘要 | The carbonylative [2+2] cycloaddition of benzyl chlorides and allyl derivatives with imines and CO for synthesis of β-lactam is effectively catalyzed by palladium/N-heterocyclic carbene complex. The desired β-lactam could be obtained in good to excellent yields (61–96%) with excellent regioselectivities (trans/cis > 95:5) and chiral lactams could be obtained with moderate diastereoselectivities. The KIE experimental studies have revealed that the C–H cleavage is most likely to be the rate-limiting step for the carbonylative cycloaddition. |
| 学科主题 | 物理化学与绿色催化 |
| 收录类别 | SCI |
| 资助信息 | the Chinese Academy of Sciences;National Natural Science Foundation of China (20802085) |
| 语种 | 英语 |
| WOS记录号 | WOS:000301692400021 |
| 公开日期 | 2013-10-11 |
| 源URL | [http://210.77.64.217/handle/362003/3880]  |
| 专题 | 兰州化学物理研究所_OSSO国家重点实验室 |
| 作者单位 | Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jie P,Qian B,Huang HM,et al. Stereoselective synthesis of trans beta-lactams via palladium/N-heterocyclic carbene-catalyzed carbonylative [2+2] cycloaddition[J]. Tetrahedron Letters,2012,53(13):1613-1616. |
| APA | Jie P,Qian B,Huang HM,&Xia CG.(2012).Stereoselective synthesis of trans beta-lactams via palladium/N-heterocyclic carbene-catalyzed carbonylative [2+2] cycloaddition.Tetrahedron Letters,53(13),1613-1616. |
| MLA | Jie P,et al."Stereoselective synthesis of trans beta-lactams via palladium/N-heterocyclic carbene-catalyzed carbonylative [2+2] cycloaddition".Tetrahedron Letters 53.13(2012):1613-1616. |
入库方式： OAI收割
来源：兰州化学物理研究所
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