Controlled sequential in situ self-assembly and disassembly of a fluorogenic cisplatin prodrug for cancer theranostics
文献类型：期刊论文
| 作者 | Xidan Wen3; Rui Zhang2; Yuxuan Hu3; Luyan Wu3; He Bai3; Dongfan Song3; Yanfeng Wang3; Ruibing An3; Jianhui Weng3; Shuren Zhang3 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2023 |
| 卷号 | 14期号:1页码:1 |
| ISSN号 | 2041-1723 |
| 英文摘要 | Temporal control of delivery and release of drugs in tumors are important in improving therapeutic outcomes to patients. Here, we report a sequential stimuli-triggered in situ self-assembly and disassembly strategy to direct delivery and release of theranostic drugs in vivo. Using cisplatin as a model anticancer drug, we design a stimuli-responsive small-molecule cisplatin prodrug (P-CyPt), which undergoes extracellular alkaline phosphatase-triggered in situ self-assembly and succeeding intracellular glutathione-triggered disassembly process, allowing to enhance accumulation and elicit burst release of cisplatin in tumor cells. Compared with cisplatin, P-CyPt greatly improves antitumor efficacy while mitigates off-target toxicity in mice with subcutaneous HeLa tumors and orthotopic HepG2 liver tumors after systemic administration. Moreover, P-CyPt also produces activated near-infrared fluorescence (at 710?nm) and dual photoacoustic imaging signals (at 700 and 750?nm), permitting high sensitivity and spatial-resolution delineation of tumor foci and real-time monitoring of drug delivery and release in vivo. This strategy leverages the advantages offered by in situ self-assembly with those of intracellular disassembly, which may act as a general platform for the design of prodrugs capable of improving drug delivery for cancer theranostics. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304727]  |
| 专题 | 新药研究国家重点实验室 |
| 作者单位 | 1.Jiangsu Institute of Nuclear Medicine 2.中国科学院上海药物研究所 3.南京大学 |
| 推荐引用方式 GB/T 7714 | Xidan Wen,Rui Zhang,Yuxuan Hu,et al. Controlled sequential in situ self-assembly and disassembly of a fluorogenic cisplatin prodrug for cancer theranostics[J]. NATURE COMMUNICATIONS,2023,14(1):1. |
| APA | Xidan Wen.,Rui Zhang.,Yuxuan Hu.,Luyan Wu.,He Bai.,...&Deju Ye.(2023).Controlled sequential in situ self-assembly and disassembly of a fluorogenic cisplatin prodrug for cancer theranostics.NATURE COMMUNICATIONS,14(1),1. |
| MLA | Xidan Wen,et al."Controlled sequential in situ self-assembly and disassembly of a fluorogenic cisplatin prodrug for cancer theranostics".NATURE COMMUNICATIONS 14.1(2023):1. |
入库方式： OAI收割
来源：上海药物研究所
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