A Rhein-Based Rh(lll) Arene Complex with Anti-tumor Cell Proliferative Activity Inhibits RNA Demethylase FTO
文献类型：期刊论文
| 作者 | Liu Lu4; Kong Yaqiong4; He Liang3; Wang Xiuxiu2; Wang Mengmeng4; Xu Hongjiao1; Yang Caiguang1 ; Su Zhi4; Zhao Jing2; Mao Zongwan3
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| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2022 |
| 卷号 | 40期号:10页码:1156 |
| ISSN号 | 1001-604X |
| 关键词 | Rhodium mRNA Antiproliferation FTO m~6A |
| 英文摘要 | Metallodrugs with fine-tuned coordination between metals and bioactive ligands can achieve cytotoxic effects in cancer therapy and have been considered as a new approach for drug design. However, it has yet to be elucidated whether these metallodrugs target epitranscriptomic proteins for gene expression regulation. This report describes a rhein-based Rh(lll)-arene complex, Rhl, that exhibited promising antiproliferative effects in several tumor cell lines. Rhl induced cell death through the autophagy, cell cycle arrest, and accumulation of intracellular reactive oxygen species (ROS). In addition, Rhl upregulated the global N~6-methyladenosine (m~6A) levels in A549 cells in the fat mass-and obesity-associated protein (FTO)-dependent manner. Collectively, the metal-based FTO inhibitor Rhl effectively suppressed tumor cell proliferation and modulated the abundance of cellular m~6A, highlighting the potential of metal-based agents to target and regulate epitranscriptomics for tumor suppression. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304776]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.南京大学 3.中山大学 4.南京师范大学 |
| 推荐引用方式 GB/T 7714 | Liu Lu,Kong Yaqiong,He Liang,et al. A Rhein-Based Rh(lll) Arene Complex with Anti-tumor Cell Proliferative Activity Inhibits RNA Demethylase FTO[J]. CHINESE JOURNAL OF CHEMISTRY,2022,40(10):1156. |
| APA | Liu Lu.,Kong Yaqiong.,He Liang.,Wang Xiuxiu.,Wang Mengmeng.,...&Liu Hongke.(2022).A Rhein-Based Rh(lll) Arene Complex with Anti-tumor Cell Proliferative Activity Inhibits RNA Demethylase FTO.CHINESE JOURNAL OF CHEMISTRY,40(10),1156. |
| MLA | Liu Lu,et al."A Rhein-Based Rh(lll) Arene Complex with Anti-tumor Cell Proliferative Activity Inhibits RNA Demethylase FTO".CHINESE JOURNAL OF CHEMISTRY 40.10(2022):1156. |
入库方式： OAI收割
来源：上海药物研究所
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