Flavonoids from the roots and rhizomes of Sophora tonkinensis and their in vitro anti-SARS-CoV-2 activity
文献类型：期刊论文
| 作者 | Li Zhuo3; Xie Hang3; Tang Chunping2 ; Feng Lu2; Ke Changqiang2; Xu Yechun1; Su Haixia2; Yao Sheng2; Ye Yang3
|
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2023 |
| 卷号 | 21期号:1页码:65 |
| ISSN号 | 2095-6975 |
| 关键词 | Sophora tonkinensis Flavonoid Anti-SARS-CoV-2 activity SARS-CoV-2 3CLpro SARS-CoV-2 PLpro |
| 英文摘要 | Acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had caused a global pandemic since 2019, and posed a serious threat to global health security. Traditional Chinese medicine (TCM) has played an indispensable role in the battle against the epidemic. Many components originated from TCMs were found to inhibit the production of SARS-CoV-2 3C-like protease (3CLpro) and papain-like protease (PLpro), which are two promising therapeutic targets to inhibit SARS-CoV-2. This study describes a systematic investigation of the roots and rhizomes of Sophora tonkinensis, which results in the characterization of 12 new flavonoids, including seven prenylated flavanones (1-7), one prenylated flavonol (8), two prenylated chalcones (9-10), one isoflavanone (11), and one isoflavan dimer (12), together with 43 known compounds (13-55). Their structures including the absolute configurations were elucidated by comprehensive analysis of MS, 1D and 2D NMR data, and time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculations. Compounds 12 and 51 exhibited inhibitory effects against SARS-CoV-2 3CLpro with IC_(50) values of 34.89 and 19.88 μmol·L~(-1), repectively while compounds 9, 43 and 47 exhibited inhibitory effects against PLpro with IC_(50) values of 32.67, 79.38, and 16.74 μmol·L~(-1), respectively. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304809]  |
| 专题 | 新药研究国家重点实验室 |
| 作者单位 | 1.中国科学院大学 2.中国科学院上海药物研究所 3.南京中医药大学 |
| 推荐引用方式 GB/T 7714 | Li Zhuo,Xie Hang,Tang Chunping,et al. Flavonoids from the roots and rhizomes of Sophora tonkinensis and their in vitro anti-SARS-CoV-2 activity[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2023,21(1):65. |
| APA | Li Zhuo.,Xie Hang.,Tang Chunping.,Feng Lu.,Ke Changqiang.,...&Ye Yang.(2023).Flavonoids from the roots and rhizomes of Sophora tonkinensis and their in vitro anti-SARS-CoV-2 activity.CHINESE JOURNAL OF NATURAL MEDICINES,21(1),65. |
| MLA | Li Zhuo,et al."Flavonoids from the roots and rhizomes of Sophora tonkinensis and their in vitro anti-SARS-CoV-2 activity".CHINESE JOURNAL OF NATURAL MEDICINES 21.1(2023):65. |
入库方式： OAI收割
来源：上海药物研究所
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