Inhibiting Hvl channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects
文献类型：期刊论文
| 作者 | Zhang Qiansen3; Ren Yimin2; Mo Yiqing3; Guo Peipei3; Liao Ping2; Luo Yuncheng2; Mu Jie2; Chen Zhuo2; Zhang Yang3; Li Ya3 |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2022 |
| 卷号 | 32期号:5页码:461 |
| ISSN号 | 1001-0602 |
| 英文摘要 | Both opioids and nonsteroidal anti-inflammatory drugs (NSAIDS) produce deleterious side effects and fail to provide sustained relief in patients with chronic inflammatory pain. Peripheral neuroinflammation (PN) is critical for initiation and development of inflammatory pain. A better understanding of molecular mechanisms underlying PN would facilitate the discovery of new analgesic targets and the development of new therapeutics. Emerging evidence suggests that peripheral sensory neurons are not only responders to painful stimuli, but are also actively engaged in inflammation and immunity, whereas the intrinsic regulatory mechanism is poorly understood. Here we report the expression of proton-selective ion channel Hv1 in peripheral sensory neurons in rodents and humans, which was previously shown as selectively expressed in microglia in mammalian central nervous system. Neuronal Hv1 was up-regulated by PN or depolarizing stimulation, which in turn aggravates inflammation and nociception. Inhibiting neuronal Hv1 genetically or by a newly discovered selective inhibitor YHV98-4 reduced intracellular alkalization and ROS production in inflammatory pain, mitigated the imbalance in downstream SHP-1-pAKT signaling, and also diminished proinflammatory chemokine release to alleviate nociception and morphine-induced hyperalgesia and tolerance. Thus, our data reveal neuronal Hv1 as a novel target in analgesia strategy and managing opioids-related side effects. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304824]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.四川大学 3.华东师范大学 |
| 推荐引用方式 GB/T 7714 | Zhang Qiansen,Ren Yimin,Mo Yiqing,et al. Inhibiting Hvl channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects[J]. CELL RESEARCH,2022,32(5):461. |
| APA | Zhang Qiansen.,Ren Yimin.,Mo Yiqing.,Guo Peipei.,Liao Ping.,...&Jiang Ruotian.(2022).Inhibiting Hvl channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects.CELL RESEARCH,32(5),461. |
| MLA | Zhang Qiansen,et al."Inhibiting Hvl channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects".CELL RESEARCH 32.5(2022):461. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。