Anti-PD-Ll mediating tumor-targeted codelivery of liposomal irinotecan/JQl for chemo-immunotherapy
文献类型：期刊论文
| 作者 | He Zhidi; Zhang Meng; Wang Yonghui; He Yang; Wang Hairui; Chen Binfan; Tu Bin; Zhu Siqi; Huang Yongzhuo
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2021 |
| 卷号 | 42期号:9页码:1516 |
| 关键词 | tumor-targeted delivery immunogenic cell death PD-1/PD-L1 blockade tumor immune microenvironment irinotecan JQ1 immune checkpoint |
| ISSN号 | 1671-4083 |
| 英文摘要 | Immune checkpoint blockade therapy has become a first-line treatment in various cancers. But there are only a small percent of colorectal patients responding to PD-1/PD-L1 blockage immunotherapy. How to increase their treatment efficacy is an urgent and clinically unmet need. It is acknowledged that immunogenic cell death (ICD)induced by some specific chemotherapy can enhance antitumor immunity. Chemo-based combination therapy can yield improved outcomes by activating the immune system to eliminate the tumor, compared with monotherapy. Here, we develop a PD-L1-targeting immune liposome (P-Lipo)for co-delivering irinotecan (IRI)and JQ1, and this system can successfully elicit antitumor immunity in colorectal cancer through inducing ICD by IRI and interfering in the immunosuppressive PD-1/PD-L1 pathway by JQ1. P-Lipo increases intratumoral drug accumulation and promotes DC maturation, and thereby facilitates adaptive immune responses against tumor growth. The remodeling tumor immune microenvironment was reflected by the increased amount of CD8~+ T cells and the release of IFN-γ, and the reduced CD4~+Foxp3~+ regulatory T cells (Tregs). Collectively, the P-Lipo codelivery system provides a chemo-immunotherapy strategy that can effectively remodel the tumor immune microenvironment and activate the host immune system and arrest tumor growth. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304830]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | He Zhidi,Zhang Meng,Wang Yonghui,et al. Anti-PD-Ll mediating tumor-targeted codelivery of liposomal irinotecan/JQl for chemo-immunotherapy[J]. ACTA PHARMACOLOGICA SINICA,2021,42(9):1516. |
| APA | He Zhidi.,Zhang Meng.,Wang Yonghui.,He Yang.,Wang Hairui.,...&Huang Yongzhuo.(2021).Anti-PD-Ll mediating tumor-targeted codelivery of liposomal irinotecan/JQl for chemo-immunotherapy.ACTA PHARMACOLOGICA SINICA,42(9),1516. |
| MLA | He Zhidi,et al."Anti-PD-Ll mediating tumor-targeted codelivery of liposomal irinotecan/JQl for chemo-immunotherapy".ACTA PHARMACOLOGICA SINICA 42.9(2021):1516. |
入库方式： OAI收割
来源：上海药物研究所
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