Macrocyclic Nonapeptides Incorporating Uncharacterized Amino Acids with Inhibitory Effects on Th17 Differentiation
文献类型：期刊论文
| 作者 | Ji Kailong2; Fan Yaoyue2; Kuok Hioha1; Liu Qunfang2 ; Li Ting1; Yue Jianmin2
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| 刊名 | CCS CHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 3期号:2页码:175 |
| 关键词 | natural products Glycosmis pentaphylla cyclopeptides Th17 differentiation inhibitors RORγt LBD blockers |
| ISSN号 | 2096-5745 |
| 英文摘要 | Four unprecedented macrocyclic nonapeptides, orberryamides A-D (1-4), were isolated from Glycosmis pentaphylla (orangeberry) and structurally characterized by obtaining solid data from numerous analytical measurements. Compound 1 incorporated a new amino acid residue, named orangeberrine (Orgb), compounds 2 and 3 integrated the rare, non-proteinogenic amino acid residues (Kyn and Dioia, respectively), and compound 4 existed as two major conformational isomers in solution at ambient temperature. The biosynthetic pathways proposed for compounds 1-4 are of considerable biological significance for the modification and metabolism of tryptophan (Trp) and/or Trp containing proteins in nature. Besides, compounds 1-4 suppressed Th17 differentiation significantly, and the effects of 1-3 was achieved through targeting the ligand-binding domain (LBD) of the retinoic acid-related orphan receptor gamma t (RORγt). |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304836]  |
| 专题 | 新药研究国家重点实验室 |
| 作者单位 | 1.澳门科技大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Ji Kailong,Fan Yaoyue,Kuok Hioha,et al. Macrocyclic Nonapeptides Incorporating Uncharacterized Amino Acids with Inhibitory Effects on Th17 Differentiation[J]. CCS CHEMISTRY,2021,3(2):175. |
| APA | Ji Kailong,Fan Yaoyue,Kuok Hioha,Liu Qunfang,Li Ting,&Yue Jianmin.(2021).Macrocyclic Nonapeptides Incorporating Uncharacterized Amino Acids with Inhibitory Effects on Th17 Differentiation.CCS CHEMISTRY,3(2),175. |
| MLA | Ji Kailong,et al."Macrocyclic Nonapeptides Incorporating Uncharacterized Amino Acids with Inhibitory Effects on Th17 Differentiation".CCS CHEMISTRY 3.2(2021):175. |
入库方式： OAI收割
来源：上海药物研究所
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