Electrochemical Rhodium-Catalyzed Enantioselective C-H Annulation with Alkynes
文献类型：期刊论文
| 作者 | Huang Yuanqiong2; Wu Zhijie2; Zhu Li2; Gu Qing2; Lu Xiaojie1 ; You Shuli2; Mei Tiansheng2
|
| 刊名 | CCS CHEMISTRY
 |
| 出版日期 | 2022 |
| 卷号 | 4期号:9页码:3181 |
| 关键词 | organic electrochemistry enantioselective C-H annulation rhodium catalysis chiral spiropyrazolones C-H functionalization |
| ISSN号 | 2096-5745 |
| 英文摘要 | The synergistic use of transition metal catalysis and electrochemistry is an attractive strategy for oxidative site-selective C-H functionalization since the use of stoichiometric chemical oxidants can be avoided and novel reactivity can be achieved. However, metal-catalyzed electrochemical C-H functionalization is mainly limited to arene C(sp~2)-H functionalization, and enantioselective C-H functionalization is uncommon and remains challenging. Herein, we report an electrochemically tuned rhodium-catalyzed enantioselective C-H annulation with alkynes, affording various spiropyrazolones in good yields and enantioselectivity in an undivided cell at room temperature. Notably, unsymmetrical alkylarylacetylenes are also efficiently converted to their corresponding spiroannulation products with excellent regioselectivity and good enantioselectivity. Thus, the protocol provides a practical and environmentally benign tool for forging chiral spiropyrazolones, which are important structural motifs found in pharmaceuticals and biologically active molecules. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304839]  |
| 专题 | 新药研究国家重点实验室 |
| 作者单位 | 1.中国科学院上海药物研究所 2.中国科学院上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Huang Yuanqiong,Wu Zhijie,Zhu Li,et al. Electrochemical Rhodium-Catalyzed Enantioselective C-H Annulation with Alkynes[J]. CCS CHEMISTRY,2022,4(9):3181. |
| APA | Huang Yuanqiong.,Wu Zhijie.,Zhu Li.,Gu Qing.,Lu Xiaojie.,...&Mei Tiansheng.(2022).Electrochemical Rhodium-Catalyzed Enantioselective C-H Annulation with Alkynes.CCS CHEMISTRY,4(9),3181. |
| MLA | Huang Yuanqiong,et al."Electrochemical Rhodium-Catalyzed Enantioselective C-H Annulation with Alkynes".CCS CHEMISTRY 4.9(2022):3181. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。