Recent advances in developing active targeting and multifunctional drug delivery systems via bioorthogonal chemistry
文献类型：期刊论文
| 作者 | Yi Wenzhe; Xiao Ping; Liu Xiaochen; Zhao Zitong; Sun Xiangshi; Wang Jue; Zhou Lei; Wang Guanru; Cao Haiqiang; Wang Dangge |
| 刊名 | SIGNAL TRANSDUCTION AND TARGETED THERAPY
 |
| 出版日期 | 2023 |
| 卷号 | 8期号:1页码:13 |
| ISSN号 | 2095-9907 |
| 英文摘要 | Bioorthogonal chemistry reactions occur in physiological conditions without interfering with normal physiological processes.Through metabolic engineering,bioorthogonal groups can be tagged onto cell membranes,which selectively attach to cargos with paired groups via bioorthogonal reactions.Due to its simplicity,high efficiency,and specificity,bioorthogonal chemistry has demonstrated great application potential in drug delivery.On the one hand,bioorthogonal reactions improve therapeutic agent delivery to target sites,overcoming off-target distribution.On the other hand,nanoparticles and biomolecules can be linked to cell membranes by bioorthogonal reactions,providing approaches to developing multi-functional drug delivery systems (DDSs).In this review,we first describe the principle of labeling cells or pathogenic microorganisms with bioorthogonal groups.We then highlight recent breakthroughs in developing active targeting DDSs to tumors,immune systems,or bacteria by bioorthogonal chemistry,as well as applications of bioorthogonal chemistry in developing functional bio-inspired DDSs (biomimetic DDSs,cell-based DDSs,bacteria-based and phage-based DDSs) and hydrogels.Finally,we discuss the difficulties and prospective direction of bioorthogonal chemistry in drug delivery.We expect this review will help us understand the latest advances in the development of active targeting and multi-functional DDSs using bioorthogonal chemistry and inspire innovative applications of bioorthogonal chemistry in developing smart DDSs for disease treatment. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304854]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Yi Wenzhe,Xiao Ping,Liu Xiaochen,et al. Recent advances in developing active targeting and multifunctional drug delivery systems via bioorthogonal chemistry[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY,2023,8(1):13. |
| APA | Yi Wenzhe.,Xiao Ping.,Liu Xiaochen.,Zhao Zitong.,Sun Xiangshi.,...&Li Yaping.(2023).Recent advances in developing active targeting and multifunctional drug delivery systems via bioorthogonal chemistry.SIGNAL TRANSDUCTION AND TARGETED THERAPY,8(1),13. |
| MLA | Yi Wenzhe,et al."Recent advances in developing active targeting and multifunctional drug delivery systems via bioorthogonal chemistry".SIGNAL TRANSDUCTION AND TARGETED THERAPY 8.1(2023):13. |
入库方式： OAI收割
来源：上海药物研究所
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