A novel alkaloid compound, DCZ0358, exerts significant antitumor activity in bortezomib-resistant multiple myeloma cells through inhibition of JAK2/STAT3 pathway
文献类型：期刊论文
| 作者 | Zhang Bibo3; Li Bo2; Xie Yongsheng3; Chang Shuaikang3; Xu Zhijian2 ; Hu Huifang2; Chen Gege3; Zhang Ting3; He Jun3; Wu Xiaosong3
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| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2023 |
| 卷号 | 55期号:2页码:215 |
| ISSN号 | 1672-9145 |
| 关键词 | DCZ0358 apoptosis cell cycle arrest multiple myeloma JAK2/STAT3 pathway |
| 英文摘要 | Multiple myeloma(MM), the second most common haematological malignancy, is currently incurable because patients often develop multiple drug resistance and experience subsequent relapse of the disease. This study aims to identify a potential therapeutic agent that can counter bortezomib(BTZ) resistance in MM. DCZ0358, a novel alkaloid compound, is found to exert potent cytotoxic effects against BTZ-resistant MM cells in vivo and in vitro. The antimyeloma activity of DCZ0358 is associated with inhibition of cell proliferation, promotion of cell apoptosis via caspase- mediated apoptotic pathways, and induction of G0/G1 phase arrest via downregulation of cyclin D1, CDK4, and CDK6. Further investigation of the molecular mechanism shows that DCZ0358 suppresses the JAK2/STAT3 signaling pathway. In conclusion, DCZ0358 can successfully counter BTZ resistance in MM cells. This study provides evidence that warrants future preclinical assessments of DCZ0358 as a therapeutic agent against BTZ resistance in MM. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304958]  |
| 专题 | 新药研究国家重点实验室 |
| 作者单位 | 1.宁波大学 2.中国科学院上海药物研究所 3.同济大学 |
| 推荐引用方式 GB/T 7714 | Zhang Bibo,Li Bo,Xie Yongsheng,et al. A novel alkaloid compound, DCZ0358, exerts significant antitumor activity in bortezomib-resistant multiple myeloma cells through inhibition of JAK2/STAT3 pathway[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2023,55(2):215. |
| APA | Zhang Bibo.,Li Bo.,Xie Yongsheng.,Chang Shuaikang.,Xu Zhijian.,...&Shi Jumei.(2023).A novel alkaloid compound, DCZ0358, exerts significant antitumor activity in bortezomib-resistant multiple myeloma cells through inhibition of JAK2/STAT3 pathway.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,55(2),215. |
| MLA | Zhang Bibo,et al."A novel alkaloid compound, DCZ0358, exerts significant antitumor activity in bortezomib-resistant multiple myeloma cells through inhibition of JAK2/STAT3 pathway".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 55.2(2023):215. |
入库方式： OAI收割
来源：上海药物研究所
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