Curcumin nanoparticles combined with 3D printed bionic tumor models for breast cancer treatment
文献类型：期刊论文
| 作者 | Su,Ya4; Hu,Xueyan4; Kang,Yue5; Zhang,Cheng4; Cheng,Yuen Yee6; Jiao,Zeren1; Nie,Yi2,3; Song,Kedong4 |
| 刊名 | Biofabrication
 |
| 出版日期 | 2022-12-08 |
| 卷号 | 15期号:1 |
| 关键词 | Chinese medicine nanoparticles 3D cell model tumor treatment drug screening |
| ISSN号 | 1758-5082 |
| DOI | 10.1088/1758-5090/aca5b8 |
| 英文摘要 | Abstract Compared with conventional therapeutic approaches, nanomedicines are attracting a growing interest due to their better targeting ability, higher delivery efficiency, and good water solubility. However, conventional drug efficacy assessment methods are based on a two-dimensional (2D) culture approach of single cells to obtain in vitro therapeutic effects, which may not be representative of actual tumors. Based on the above considerations, the three-dimensional (3D) cell culture models became a better choice since they can increase the complexity of in vitro systems and provide a biomimetic microenvironment that is closer to the in vivo native than 2D cultures. In our study, curcumin nanoparticle (CurNPs) with good water solubility and good tumor therapeutic effects were prepared by combining polymeric non-ionic surfactant (Pluronic F127) with curcumin. The hybrid scaffolds based on nano-clay, sodium alginate, and gelatin were also prepared, which showed good printability and excellent biocompatibility. We then studied the therapeutic effects of CurNPs on metastatic breast cancer using a 3D tumor model fabricated with scaffold-bound metastatic breast cancer (MDA-MB-231) cells. It was showed that the 3D cell model presented better cell proliferation effect while compared with 2D version. Additionally, there was good enhanced permeability and retention effect when CurNPs entered with better accumulate in 3D cell ‘tumor’ sites which represented more realistic response of a more real tumor treatment effect for breast cancer cells. Our study indicated that the combinational of nanomaterials with 3D cell ‘tumor’ models provided an alternative and better platform for drug screening and has great potential be used as safe and effective treatment screening for breast cancer. |
| 语种 | 英语 |
| WOS记录号 | IOP:BF_15_1_014105 |
| 出版者 | IOP Publishing |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/56608]  |
| 通讯作者 | Song,Kedong |
| 作者单位 | 1.Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas, TX 77843-3122, United States of America 2.Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China 3.Zhengzhou Institute of Emerging Industrial Technology, Zhengzhou 450000, People’s Republic of China 4.State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, People’s Republic of China 5.Department of Breast Surgery, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Shenyang 110042, People’s Republic of China 6.Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia |
| 推荐引用方式 GB/T 7714 | Su,Ya,Hu,Xueyan,Kang,Yue,et al. Curcumin nanoparticles combined with 3D printed bionic tumor models for breast cancer treatment[J]. Biofabrication,2022,15(1). |
| APA | Su,Ya.,Hu,Xueyan.,Kang,Yue.,Zhang,Cheng.,Cheng,Yuen Yee.,...&Song,Kedong.(2022).Curcumin nanoparticles combined with 3D printed bionic tumor models for breast cancer treatment.Biofabrication,15(1). |
| MLA | Su,Ya,et al."Curcumin nanoparticles combined with 3D printed bionic tumor models for breast cancer treatment".Biofabrication 15.1(2022). |
入库方式： OAI收割
来源：过程工程研究所
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