Optimization of cyclodextrin-assisted green extraction of cannabidiol from industrial hemp leaves: Release behavior, permeability, bioactivity, and stability
文献类型：期刊论文
| 作者 | Li, Hang1,2; Zhao, Qing-Sheng1,2; Wang, Li-Wei1; Chang, Sen-Lin1,2; Wang, Pei-Dong1,2; Zhao, Bing1 |
| 刊名 | INDUSTRIAL CROPS AND PRODUCTS
 |
| 出版日期 | 2022-11-15 |
| 卷号 | 188页码:11 |
| ISSN号 | 0926-6690 |
| 关键词 | Cannabidiol Cyclodextrin Response surface methodology Extraction Release behavior Permeability |
| DOI | 10.1016/j.indcrop.2022.115709 |
| 英文摘要 | Cannabidiol (CBD) is an important natural compound of hemp. Cyclodextrin-assisted extraction of CBD from hemp leaves was optimized by single-factor experiments and response surface methodology. The highest extraction yield of CBD was 1.075 +/- 0.012 mg/g and the recovery yield was 87.19 % using dimethyl-beta-cyclodextrin (DM-beta CD), which showed that the extract had a higher proportion of CBD. The optimal conditions were as follows: extraction temperature was 40 degrees C, liquid-to-solid ratio was 25.17 mL/g, extraction time was 74.4 min, mass ratio of DM-beta CD to hemp leaves was 1.17, and ethanol concentration was 60 %. Different characterizations demonstrated that complexation of DM-beta CD promoted CBD extraction and increased the proportion of CBD in the extract. The cumulative release rate of CBD (67.98%) from the extract by DM-beta CD-assisted extraction (DAHE) was much higher than that (2.62%) without DM-beta CD-assisted extraction (HE). The permeability, bioactivity, and stability of DAHE were also better than that of HE. The better results of DAHE could be due to the inclusion by DM-beta CD and the higher proportion of CBD. In conclusion, DM-beta CD-assisted extraction was an appropriate method for CBD extraction and the obtained extract with higher CBD proportion and better bioactivity and stability could be applied in many fields. |
| WOS关键词 | BETA-CYCLODEXTRIN ; ANTIOXIDANT ACTIVITY ; COMPLEXES |
| 资助项目 | Yunnan Hempmon Pharmaceutical Co., Ltd. |
| WOS研究方向 | Agriculture |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000910922600007 |
| 资助机构 | Yunnan Hempmon Pharmaceutical Co., Ltd. |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/56678]  |
| 通讯作者 | Zhao, Qing-Sheng; Zhao, Bing |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Hang,Zhao, Qing-Sheng,Wang, Li-Wei,et al. Optimization of cyclodextrin-assisted green extraction of cannabidiol from industrial hemp leaves: Release behavior, permeability, bioactivity, and stability[J]. INDUSTRIAL CROPS AND PRODUCTS,2022,188:11. |
| APA | Li, Hang,Zhao, Qing-Sheng,Wang, Li-Wei,Chang, Sen-Lin,Wang, Pei-Dong,&Zhao, Bing.(2022).Optimization of cyclodextrin-assisted green extraction of cannabidiol from industrial hemp leaves: Release behavior, permeability, bioactivity, and stability.INDUSTRIAL CROPS AND PRODUCTS,188,11. |
| MLA | Li, Hang,et al."Optimization of cyclodextrin-assisted green extraction of cannabidiol from industrial hemp leaves: Release behavior, permeability, bioactivity, and stability".INDUSTRIAL CROPS AND PRODUCTS 188(2022):11. |
入库方式： OAI收割
来源：过程工程研究所
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