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Bioactive Peptide Nanodrugs Based on Supramolecular Assembly for Boosting Immunogenic Cell Death-Induced Cancer Immunotherapy

文献类型：期刊论文

作者Liu, Yamei1; Chang, Rui1; Xing, Ruirui1,2; Yan, Xuehai1,2,3
刊名SMALL METHODS
出版日期2023-01-31
页码12
ISSN号2366-9608
关键词bioactive peptides cancer immunotherapy delivery platforms immunogenic cell death self-assembly
DOI10.1002/smtd.202201708
英文摘要Immunogenic cell death (ICD)-induced immunotherapy holds promise for complete elimination and long-term protective immune responses against cancer by combining direct tumor cell killing and antitumor immune response. Some therapeutic approaches (such as hyperthermia, photodynamic therapy, or radiotherapy) and inducers (certain chemotherapy drugs, oncolytic viruses) have been devoted to initiating and/or boosting ICD, leading to the activation of tumor-specific immune responses. Recently, supramolecular assembled bioactive peptide nanodrugs have been employed to improve the efficacy of ICD-induced cancer immunotherapy by increasing tumor targeted accumulation as well as responsive release of ICD inducers, directly inducing high levels of ICD and realizing the simultaneous enhancement of immune response through the immune function of the active peptide itself. Here, the authors review bioactive peptide nanodrugs based on supramolecular assembly, mainly as an intelligent delivery system, a direct ICD inducer and an immune response enhancer, for boosting ICD induced cancer immunotherapy. The functions of diverse bioactive peptides used in the construction of nanodrugs are described. The design of a supramolecular assembly, the mechanism of boosting ICD, and synergetic effects of bioactive peptides combined immunotherapy are critically emphasized.
WOS关键词IMMUNE-RESPONSES ; DELIVERY-SYSTEMS ; HYDROGELS ; LTX-315 ; STRATEGY ; NGR
资助项目National Science Fund for Distinguished Young Scholars of China[22025207] ; National Natural Science Foundation of China[22102188] ; National Natural Science Foundation of China[22072154] ; National Natural Science Foundation of China[22232006] ; Chinese Postdoctoral Science Foundation[2020M680674] ; National Natural Science Foundation of Hebei Province[B2020103025]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000919949200001
资助机构National Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; Chinese Postdoctoral Science Foundation ; National Natural Science Foundation of Hebei Province
源URL[http://ir.ipe.ac.cn/handle/122111/56682]  
通讯作者Xing, Ruirui; Yan, Xuehai
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Yamei,Chang, Rui,Xing, Ruirui,et al. Bioactive Peptide Nanodrugs Based on Supramolecular Assembly for Boosting Immunogenic Cell Death-Induced Cancer Immunotherapy[J]. SMALL METHODS,2023:12.
APA Liu, Yamei,Chang, Rui,Xing, Ruirui,&Yan, Xuehai.(2023).Bioactive Peptide Nanodrugs Based on Supramolecular Assembly for Boosting Immunogenic Cell Death-Induced Cancer Immunotherapy.SMALL METHODS,12.
MLA Liu, Yamei,et al."Bioactive Peptide Nanodrugs Based on Supramolecular Assembly for Boosting Immunogenic Cell Death-Induced Cancer Immunotherapy".SMALL METHODS (2023):12.

入库方式： OAI收割

来源：过程工程研究所

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