Nucleic acid drug vectors for diagnosis and treatment of brain diseases
文献类型：期刊论文
| 作者 | Lu, Zhi-Guo1,2; Shen, Jie1,2; Yang, Jun1,2; Wang, Jing-Wen1; Zhao, Rui-Chen1,2; Zhang, Tian-Lu1; Guo, Jing1; Zhang, Xin1,2 |
| 刊名 | SIGNAL TRANSDUCTION AND TARGETED THERAPY
 |
| 出版日期 | 2023-01-17 |
| 卷号 | 8期号:1页码:53 |
| ISSN号 | 2095-9907 |
| DOI | 10.1038/s41392-022-01298-z |
| 英文摘要 | Nucleic acid drugs have the advantages of rich target selection, simple in design, good and enduring effect. They have been demonstrated to have irreplaceable superiority in brain disease treatment, while vectors are a decisive factor in therapeutic efficacy. Strict physiological barriers, such as degradation and clearance in circulation, blood-brain barrier, cellular uptake, endosome/lysosome barriers, release, obstruct the delivery of nucleic acid drugs to the brain by the vectors. Nucleic acid drugs against a single target are inefficient in treating brain diseases of complex pathogenesis. Differences between individual patients lead to severe uncertainties in brain disease treatment with nucleic acid drugs. In this Review, we briefly summarize the classification of nucleic acid drugs. Next, we discuss physiological barriers during drug delivery and universal coping strategies and introduce the application methods of these universal strategies to nucleic acid drug vectors. Subsequently, we explore nucleic acid drug-based multidrug regimens for the combination treatment of brain diseases and the construction of the corresponding vectors. In the following, we address the feasibility of patient stratification and personalized therapy through diagnostic information from medical imaging and the manner of introducing contrast agents into vectors. Finally, we take a perspective on the future feasibility and remaining challenges of vector-based integrated diagnosis and gene therapy for brain diseases. |
| WOS关键词 | RABIES VIRUS GLYCOPROTEIN ; NEURAL STEM-CELLS ; NF-KAPPA-B ; ACCELERATED BLOOD CLEARANCE ; SMALL INTERFERING RNA ; DOUBLE HYDROXIDE NANOPARTICLES ; RECEPTOR-MEDIATED ENDOCYTOSIS ; ENDOTHELIAL GROWTH-FACTOR ; CORE-SHELL NANOPARTICLES ; GENOME-WIDE ASSOCIATION |
| 资助项目 | National Natural Science Foundation of China[32225029] ; National Natural Science Foundation of China[22205240] ; National Natural Science Foundation of China[52073287] ; National Natural Science Foundation of China[22075289] ; National Natural Science Foundation of China[21875254] ; China Postdoctoral Science Foundation[2021M703240] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| 出版者 | SPRINGERNATURE |
| WOS记录号 | WOS:000913317800001 |
| 资助机构 | National Natural Science Foundation of China ; China Postdoctoral Science Foundation |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/56850]  |
| 通讯作者 | Lu, Zhi-Guo; Zhang, Xin |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Zhi-Guo,Shen, Jie,Yang, Jun,et al. Nucleic acid drug vectors for diagnosis and treatment of brain diseases[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY,2023,8(1):53. |
| APA | Lu, Zhi-Guo.,Shen, Jie.,Yang, Jun.,Wang, Jing-Wen.,Zhao, Rui-Chen.,...&Zhang, Xin.(2023).Nucleic acid drug vectors for diagnosis and treatment of brain diseases.SIGNAL TRANSDUCTION AND TARGETED THERAPY,8(1),53. |
| MLA | Lu, Zhi-Guo,et al."Nucleic acid drug vectors for diagnosis and treatment of brain diseases".SIGNAL TRANSDUCTION AND TARGETED THERAPY 8.1(2023):53. |
入库方式： OAI收割
来源：过程工程研究所
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