Hollow Nanomaterials in Advanced Drug Delivery Systems: From Single- to Multiple Shells
文献类型：期刊论文
| 作者 | Li, Zhao4; Xu, Ke4; Qin, Linlin4; Zhao, Decai2,3; Yang, Nailiang2,3; Wang, Dan2,3; Yang, Yang1,4 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2023-01-29 |
| 页码 | 26 |
| ISSN号 | 0935-9648 |
| 关键词 | drug delivery systems hollow multi-shelled structures nanomaterials |
| DOI | 10.1002/adma.202203890 |
| 英文摘要 | Hollow-structured nanomaterials (HSNMs) have attracted increased interest in biomedical fields, owing to their excellent potential as drug delivery systems (DDSs) for clinical applications. Among HSNMs, hollow multi-shelled structures (HoMSs) exhibit properties such as high loading capacity, sequential drug release, and multi-functionalized modification and represent a new class of nanoplatforms for clinical applications. The remarkable properties of HoMS-based DDS can simultaneously satisfy and enhance DDSs for delivering small molecular drugs (e.g., antibiotics, chemotherapy drugs, and imaging agents) and macromolecular drugs (e.g., protein/peptide- and nucleic acid-based drugs). First, the latest research advances in delivering small molecular drugs are summarized and highlight the inherent advantages of HoMS-based DDSs for small molecular drug targeting, combining continuous therapeutic drug delivery and theranostics to optimize the clinical benefit. Meanwhile, the macromolecular drugs DDSs are in the initial development stage and currently offer limited delivery modes. There is a growing need to analyze the deficiency of other HSNMs and integrate the advantages of HSNMs, providing solutions for the safe, stable, and cascade delivery of macromolecular drugs to meet vast treatment requirements. Therefore, the latest advances in HoMS-based DDSs are comprehensively reviewed, mainly focusing on the characteristics, research progress by drug category, and future research prospects. |
| WOS关键词 | MESOPOROUS SILICA NANOPARTICLES ; METAL-ORGANIC FRAMEWORKS ; MESENCHYMAL STEM-CELLS ; POLYMERIC NANOPARTICLES ; MAGNETIC NANOPARTICLES ; TARGETED DELIVERY ; PROTEIN THERAPY ; GENE DELIVERY ; PLASMID DNA ; CO-DELIVERY |
| 资助项目 | National Key R&D Program of China[2020YFA0211100] ; National Natural Science Foundation of China[51922077] ; National Natural Science Foundation of China[51872205] ; Foundation of National Facility for Translational Medicine (Shanghai)[TMSK-2020-012] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000921602100001 |
| 资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; Foundation of National Facility for Translational Medicine (Shanghai) |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/56967]  |
| 通讯作者 | Zhao, Decai; Yang, Nailiang; Yang, Yang |
| 作者单位 | 1.Tongji Univ, Sch Mat Sci & Engn, Shanghai 201804, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Tongji Univ, Shanghai Pulm Hosp, Sch Med, Dept Thorac Surg, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhao,Xu, Ke,Qin, Linlin,et al. Hollow Nanomaterials in Advanced Drug Delivery Systems: From Single- to Multiple Shells[J]. ADVANCED MATERIALS,2023:26. |
| APA | Li, Zhao.,Xu, Ke.,Qin, Linlin.,Zhao, Decai.,Yang, Nailiang.,...&Yang, Yang.(2023).Hollow Nanomaterials in Advanced Drug Delivery Systems: From Single- to Multiple Shells.ADVANCED MATERIALS,26. |
| MLA | Li, Zhao,et al."Hollow Nanomaterials in Advanced Drug Delivery Systems: From Single- to Multiple Shells".ADVANCED MATERIALS (2023):26. |
入库方式： OAI收割
来源：过程工程研究所
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