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Engineered NanoAlum from aluminum turns cold tumor hot for potentiating cancer metalloimmunotherapy

文献类型：期刊论文

作者Jia, Yingbo1,2,4,5; Hu, Jing1,3; Zhu, Chaojie1; Li, Zijing1; Yang, Xinyu1; Liu, Ruitian5; Zeng, Linghui1; Zhang, Lingxiao1,4
刊名JOURNAL OF CONTROLLED RELEASE
出版日期2023-02-01
卷号354页码:770-783
ISSN号0168-3659
关键词Aluminum adjuvants Tumor microenvironment Layered double hydroxide Metalloimmunotherapy In situ immunotherapy
DOI10.1016/j.jconrel.2023.01.043
英文摘要The poor cancer immunotherapy outcome has been closely related to immunosuppressive tumor microenvironment (TME), which usually inactivates the antitumor immune cells and leads to immune tolerance. Metalloimmunotherapy by supplementing nutritional metal ions into TME has emerged as a potential strategy to activate the tumor-resident immune cells. Herein, we engineered a magnesium-contained nano-aluminum adjuvant (NanoAlum) through hydrolyzing a mixture of Mg(OH)2 and Al(OH)3, which has highly similar components to commercial Imject Alum. Peritumoral injection of NanoAlum effectively neutralized the acidic TME while releasing Mg2+ to activate the tumor-resident T cells. Meanwhile, NanoAlum also blocked the autophagy pathway in tumor cells and subsequently induced cell apoptosis. The in vivo studies showed that merely peritumoral injection of NanoAlum successfully inhibited the growth of solid tumors in mice. On this basis, NanoAlum combined with chemical drug methotrexate or immunomodulatory adjuvant CpG further induced potent antigen-specific antitumor immunity. Overall, our study first provides a rational design for engineering tumortargeted nanomodulator from clinical adjuvants to achieve effective cancer metalloimmunotherapy against solid tumors.
WOS关键词DOUBLE HYDROXIDE NANOPARTICLES ; LAYERED DOUBLE HYDROXIDES ; MELANOMA TUMOR ; GROWTH ; INHIBITION ; AUTOPHAGY ; RESPONSES ; DELIVERY ; CELLS
资助项目National Nat- ural Science Foundation of China[32101123] ; National Nat- ural Science Foundation of China[22208287] ; Zhejiang Provincial Natural Science Foundation of China[LTY21H160001] ; Natural Science Foundation of Ningbo[2022J273] ; Natural Science Foundation of Ningbo[2021J320] ; China Postdoctoral Science Foundation[BX20220261] ; China Postdoctoral Science Foundation[2022M712736] ; China Postdoctoral Science Foundation[2021M702816]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
出版者ELSEVIER
WOS记录号WOS:000925260300001
资助机构National Nat- ural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation of China ; Natural Science Foundation of Ningbo ; China Postdoctoral Science Foundation
源URL[http://ir.ipe.ac.cn/handle/122111/56991]  
通讯作者Zeng, Linghui; Zhang, Lingxiao
作者单位1.Hangzhou City Univ, Sch Med, Key Lab Novel Targets & Drug Study Neural Repair Z, Hangzhou 310015, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
3.Zhejiang Univ, Hangzhou Global Sci & Technol Innovat Ctr, Hangzhou 211200, Peoples R China
4.Univ Chinese Acad Sci, Ningbo Inst Life & Hlth Ind, Ningbo 315010, Peoples R China
5.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Jia, Yingbo,Hu, Jing,Zhu, Chaojie,et al. Engineered NanoAlum from aluminum turns cold tumor hot for potentiating cancer metalloimmunotherapy[J]. JOURNAL OF CONTROLLED RELEASE,2023,354:770-783.
APA Jia, Yingbo.,Hu, Jing.,Zhu, Chaojie.,Li, Zijing.,Yang, Xinyu.,...&Zhang, Lingxiao.(2023).Engineered NanoAlum from aluminum turns cold tumor hot for potentiating cancer metalloimmunotherapy.JOURNAL OF CONTROLLED RELEASE,354,770-783.
MLA Jia, Yingbo,et al."Engineered NanoAlum from aluminum turns cold tumor hot for potentiating cancer metalloimmunotherapy".JOURNAL OF CONTROLLED RELEASE 354(2023):770-783.

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来源：过程工程研究所

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