Expression of TFRC helps to improve the antineoplastic effect of Ara-C on AML cells through a targeted delivery carrier
文献类型：期刊论文
| 作者 | Xinzhou Wu1; Zhouguang Jiao2; Junying Zhang2; Feng Li2; Yuhua Li1 |
| 刊名 | JOURNAL OF NANOBIOTECHNOLOGY
 |
| 出版日期 | 2023 |
| 卷号 | 21期号:1页码:1 |
| ISSN号 | 1477-3155 |
| 英文摘要 | Currently, high doses of cytarabine arabinoside (Ara-C)-based combined chemotherapy are commonly used in acute myeloid leukemia (AML) therapy, but severe adverse effects and poor suppression effects in leukemia cells limit the clinical therapeutic efficiency of Ara-C-based chemotherapy due to a lack of targeting selectivity. To improve the therapeutic effect of Ara-C in AML, here, since we confirmed that transferrin receptor 1 (TFRC) expression in AML cells was constant, we generated Ara-C@HFn by encapsulating free Ara-C into self-assembled heavy ferritin chain (HFn, the ligand of TFRC) nanocages. |
| 语种 | 英语 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/57108]  |
| 作者单位 | 1.南方医科大学 2.中国科学院过程工程研究所 |
| 推荐引用方式 GB/T 7714 | Xinzhou Wu,Zhouguang Jiao,Junying Zhang,et al. Expression of TFRC helps to improve the antineoplastic effect of Ara-C on AML cells through a targeted delivery carrier[J]. JOURNAL OF NANOBIOTECHNOLOGY,2023,21(1):1. |
| APA | Xinzhou Wu,Zhouguang Jiao,Junying Zhang,Feng Li,&Yuhua Li.(2023).Expression of TFRC helps to improve the antineoplastic effect of Ara-C on AML cells through a targeted delivery carrier.JOURNAL OF NANOBIOTECHNOLOGY,21(1),1. |
| MLA | Xinzhou Wu,et al."Expression of TFRC helps to improve the antineoplastic effect of Ara-C on AML cells through a targeted delivery carrier".JOURNAL OF NANOBIOTECHNOLOGY 21.1(2023):1. |
入库方式： OAI收割
来源：过程工程研究所
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