Wenshen Yangxue decoction (温肾养血方) promotes follicular development in aged female mice via stimulation of the silent information regulator 3/forkhead transcription factor O1 3a pathway
文献类型：期刊论文
| 作者 | Zhang Liang2; Han Qian1; Yi Yanxiao1; Ji Shaoyang3; Xin Mingwei1 |
| 刊名 | JOURNAL OF TRADITIONAL CHINESE MEDICINE
 |
| 出版日期 | 2022 |
| 卷号 | 42期号:4页码:539 |
| 关键词 | aging silent information regulator 3 forkhead transcription factors oocytes Wenshen Yangxue decoction |
| ISSN号 | 0255-2922 |
| 英文摘要 | OBJECTIVE:To primarily explore the effect and mechanism of Wenshen Yangxue decoction (温肾养血方) in promoting follicular development in elderly female mice.METHODS:Fifty Institute of Cancer Research mice were randomly divided into blank,controlled ovarian hyperstimulation (COH),low-dose Wenshen Yangxue decoction,medium-dose Wenshen Yangxue decoction,and high-dose Wenshen Yangxue decoction groups,with 10 mice in each group.The number of ovulations,number of fertilizations,mitochondrial adenosine triphosphate (ATP) level,and mitochondrial DNA (mtDNA) of oocytes in each group were compared.Reverse transcriptionpolymerase chain reaction and Western blotting were used to detect the mRNA and protein expression levels of silent information regulator 3 (Sirt3) and forkhead transcription factor O1 3a (FOXO3a).RESULTS:Wenshen Yangxue decoction significantly increased the number of ovulations in mice (P <0.05) and promoted the formation of fertilized eggs.The ATP level and mtDNA copy number of mice oocytes in the highdose groups were significantly higher than those in the COH group (P <0.05).Wenshen Yangxue decoction significantly increased the mRNA and protein levels of Sirt3 and FOXO3a in mouse oocytes.CONCLUSION:Wenshen Yangxue decoction promoted the development of follicles in elderly female mice,increased the number of ovulations and improved fertility.Its mechanism may be related to increased mitochondrial energy metabolism and regulation of the Sirt3/FOXO3a pathway. |
| 语种 | 英语 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/57124]  |
| 作者单位 | 1.Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Maternal and Child Health Care Hospital 2.Department of Clinical Laboratory Medicine,Beijing Hospital of Integrated Traditional Chinese and Western Medicine 3.中国科学院过程工程研究所 |
| 推荐引用方式 GB/T 7714 | Zhang Liang,Han Qian,Yi Yanxiao,等. Wenshen Yangxue decoction (温肾养血方) promotes follicular development in aged female mice via stimulation of the silent information regulator 3/forkhead transcription factor O1 3a pathway[J]. JOURNAL OF TRADITIONAL CHINESE MEDICINE,2022,42(4):539. |
| APA | Zhang Liang,Han Qian,Yi Yanxiao,Ji Shaoyang,&Xin Mingwei.(2022).Wenshen Yangxue decoction (温肾养血方) promotes follicular development in aged female mice via stimulation of the silent information regulator 3/forkhead transcription factor O1 3a pathway.JOURNAL OF TRADITIONAL CHINESE MEDICINE,42(4),539. |
| MLA | Zhang Liang,et al."Wenshen Yangxue decoction (温肾养血方) promotes follicular development in aged female mice via stimulation of the silent information regulator 3/forkhead transcription factor O1 3a pathway".JOURNAL OF TRADITIONAL CHINESE MEDICINE 42.4(2022):539. |
入库方式： OAI收割
来源：过程工程研究所
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