Zinc as mediator of ubiquitin conjugation following traumatic brain injury
文献类型：期刊论文
| 作者 | Sun, KJ ; Zhu, L ; Wang, HD ; Ji, XJ ; Pan, H ; Chen, M ; Lu, TJ ; Fan, YW ; Cheng, HL ; Hang, CH ; Shi, JX |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2013 |
| 卷号 | 1506期号:01页码:132-141 |
| 关键词 | MITOCHONDRIAL DYSFUNCTION HIPPOCAMPAL-NEURONS RAT HIPPOCAMPUS IN-VITRO PROTEASOME EXPRESSION PATHWAY DEATH PTEN DEUBIQUITINATION |
| ISSN号 | 0006-8993 |
| 通讯作者 | Zhu, L (reprint author), Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing 210008, Jiangsu, Peoples R China.,linzhu75@163.com |
| 英文摘要 | Previous studies have shown that pathological zinc accumulation and deposition of ubiquitinated protein aggregates are commonly detected in many acute neural injuries, such as trauma, epilepsy and ischemia. However, the underlying mechanisms are poorly understood. Here we assessed the effect of zinc on ubiquitin conjugation and subsequent neurodegeration following traumatic brain injury (TBI). First, we found that scavenging endogenous Zn2+ reduced trauma-induced ubiquitin conjugation and protected neurons from TBI insults in rat hippocampus. Second, we detected both zinc accumulation and increased ubiquitin conjugated protein following brain trauma in human cortical neurons. Our previous study has shown that zinc can induce ubiquitin conjugation in cultured hippocampal neurons. All these findings indicate that alterations in Zn2+ homeostasis may impair the protein degradation pathway and ultimately cause neuronal injury following traumatic brain injury. (C) 2013 Elsevier B.V. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | Jinling Hospital of Nanjing [10MA097]; Chines Postdoctoral Science Foundation [201150M1572]; National Natural Science Foundation of China [81271377/H0910] |
| 语种 | 英语 |
| 公开日期 | 2013-10-14 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2561]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Sun, KJ,Zhu, L,Wang, HD,et al. Zinc as mediator of ubiquitin conjugation following traumatic brain injury[J]. BRAIN RESEARCH,2013,1506(01):132-141. |
| APA | Sun, KJ.,Zhu, L.,Wang, HD.,Ji, XJ.,Pan, H.,...&Shi, JX.(2013).Zinc as mediator of ubiquitin conjugation following traumatic brain injury.BRAIN RESEARCH,1506(01),132-141. |
| MLA | Sun, KJ,et al."Zinc as mediator of ubiquitin conjugation following traumatic brain injury".BRAIN RESEARCH 1506.01(2013):132-141. |
入库方式： OAI收割
来源：上海神经科学研究所
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