Effects of ganglioside-1 loaded magnetic pluronic nanoparticles on repair of acute complete spinal cord injury
文献类型：期刊论文
| 作者 | Li Ying1; Chen Shu2; Zhao Qihuang1; Guo Chen1; Liu Huizhou1 |
| 刊名 | JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH
 |
| 出版日期 | 2009 |
| 卷号 | 13期号:16页码:3061 |
| 关键词 | 脊髓损伤 磁性纳米颗粒 神经再生 生物材料 No English Keywords |
| ISSN号 | 1673-8225 |
| 英文摘要 | BACKGROUND: Temperature-responsive magnetic pluronic nanoparticles possess the capacity of drug release controlled by body temperature and can penetrate blood brain barrier.OBJECTIVE: To detect the capacity of magnetic pluronic nanoparticles to carrying ganglioside-1(GM-1) and its capacity of drug release in vivo, as well as its effects on repair of spinal cord injury.DESIGN, TIME AND SETTING: A randomized, controlled, animal experiment was performed at the key laboratories of Beijing Institute for Neuroscience, Capital Medical University and Institute of Process Engineering, Chinese Academy of Sciences between June 2006 and February 2007.MATERIALS: GM-1 loaded magnetic pluronic nanoparticles were prepared by Laboratory of Separation Science and Engineering State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences. GM-1 was provided by Trb Pharma S.A of Argentina.METHODS: Twenty Sprague-Dawiey rats were developed into acute complete spinal cord injury models and were then evenly and randomly divided into four groups:①GM-1 loaded magnetic pluronic nanoparticles+fibrin glue(treatment group):100μL GM-1 loaded magnetic pluronic nanoparticles and 100μL fibrin glue injected into the inision.②Magnetic pluronic nanoparticles+fibrin glue(control group1):receiving 100μL magnetic pluronic nanoparticles and 100μL fibrin glue.③Fibrin glue(control goup2):administration of 100μL fibrin glue.④Sham-operation group:no treatments.MAIN OUTCOME MEASURES: Behavior evaluation and quantitative analysis (nerve fibers and glial cells) at 4 weeks post-surgery.RESULTS:All initial 20 rats were included in the final analysis.①The numbers of nerve fibers in the rostral and caudal areas were significantly greater in the treatment group than in the remaining 3 groups (P < 0.05), the control groups exhibited greater numbers of nerve fibers than the sham-operation groups, and the control group 2 had higher levels compared with the control compared with the remaining 3 groups (P < 0.05).②The area ratio of glial cells in the rostral and caudal areas was significantly higher in thetreatment group compared with the remaining3 groups(P<0.05).In the rostral areas,the control gropus exhibited higher area ratio of glial cells than the sham-operation group(P < 0.05), and in the caudal areas, control group 2 displayed higher levels compared with the sham-operation group (P < 0.05).CONCLUSION: Magnetic pluronic nanoparticles possess drug-carrying and drug-releasing capacities. GM-1 loaded magnetic pluronic nanoparticies can repair spinal cord injury and promote nerve regeneration. |
| 语种 | 英语 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/57718]  |
| 作者单位 | 1.首都医科大学 2.中国科学院过程工程研究所 |
| 推荐引用方式 GB/T 7714 | Li Ying,Chen Shu,Zhao Qihuang,et al. Effects of ganglioside-1 loaded magnetic pluronic nanoparticles on repair of acute complete spinal cord injury[J]. JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH,2009,13(16):3061. |
| APA | Li Ying,Chen Shu,Zhao Qihuang,Guo Chen,&Liu Huizhou.(2009).Effects of ganglioside-1 loaded magnetic pluronic nanoparticles on repair of acute complete spinal cord injury.JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH,13(16),3061. |
| MLA | Li Ying,et al."Effects of ganglioside-1 loaded magnetic pluronic nanoparticles on repair of acute complete spinal cord injury".JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH 13.16(2009):3061. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。