Preparation of uniform microspheres and microcapsules by modified emulsification process
文献类型：会议论文
| 作者 | Ma, Guang-Hui; Yang, Jian; Lv, Pi-Ping; Wang, Lian-Yan; Wei, Wei; Tian, Rui; Wu, Jie; Su, Zhi-Guo |
| 出版日期 | 2010-02-01 |
| 关键词 | Emulsification - Magnetite - Targeted drug delivery - Microstructure - Drops - Homogenization method - Controlled drug delivery - Emulsions - Precipitation (chemical) |
| 卷号 | 288 |
| 期号 | 1 |
| DOI | 10.1002/masy.201050206 |
| 页码 | 41-48 |
| 英文摘要 | Uniform microspheres and microcapsules have been prepared by developing a direct membrane emulsification technique from O/W, W/O and W/O/W emulsions in previous studies, and have been applied in bio-separation and drug delivery systems. The diameter can be controlled from several microns to above 100 microns. However, smaller microsphere with submicron size, especially from W/O/W emulsion was difficult to be prepared. In this article, a modified emulsification technique was developed to overcome the problem. That is, a pre-emulsion (W/O or W/O/W) with broad size distribution of droplets was prepared firstly by homogenization, sonification or mechanical stirring method, then the pre-emulsion was pressed through the uniform pores of a Shirasu Porous Glass (SPG) membrane to obtain relatively uniform smaller droplets, finally the droplets were solidified to form uniform microsphere or microcapsule. Uniform chitosan microsphere and poly(lacticglycolic acid) (PLGA) microcapsule with submicron size were prepared from W/O and W/O/W emulsions, respectively. Further more, uniform polymer-magnetite microcapsule was prepared by combining this technique and a new post-precipitation process ofmagnetite. Copyright 漏 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| 资助机构 | Wiley-VCH Verlag |
| 学科主题 | Microspheres |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/59488]  |
| 作者单位 | National Key Lab of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No.1 Bei-Er-Tiao, Zhong-Guan-Cun, Beijing 100190, China |
| 推荐引用方式 GB/T 7714 | Ma, Guang-Hui,Yang, Jian,Lv, Pi-Ping,et al. Preparation of uniform microspheres and microcapsules by modified emulsification process[C]. 见:. |
入库方式： OAI收割
来源：过程工程研究所
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