Bio-mimic particles for the enhanced vaccinations: Lessons learnt from the natural traits and pathogenic invasion
文献类型：期刊论文
| 作者 | Wu, Sihua2,3; Xia, Yufei1,3; Hu, Yuning1,3; Ma, Guanghui1,2,3 |
| 刊名 | Advanced Drug Delivery Reviews
 |
| 出版日期 | 2021-09-01 |
| 卷号 | 176 |
| 关键词 | Biomimetics - Antibodies - Immune system - T-cells - Pathogens - Antigens |
| ISSN号 | 0169409X |
| DOI | 10.1016/j.addr.2021.113871 |
| 英文摘要 | In the combat against pathogens, the immune systems were evolved with the immune recognitions against the various danger signals, which responded vigorously upon the pathogen invasions and elicited potent antibodies or T cell engagement against the re-infections. Envisage with the prevailing pandemics and increasing demands for cancer vaccines, bio-mimic particles were developed to imitate the natural traits of the pathogens, which conferred the optimal strategies to stimulate the immune engagement and let to the increased vaccine efficacy. Here, the recent development in bio-mimic particles, as well as the natural cues from the pathogens were discussed. As such, the designing principles that adapted from the physiochemical properties of the pathogens were unfolded as the surface characteristics (hydrophobic, nano-pattern, antigen display, charge), properties (size, shape, softness) and the delivered components (peptide, protein, nuclear acids, toll-like receptor (TLR) agonist, antibody). Additionally, the strategies for the efficient delivery, regarding the biodistribution, internalization and presentation of the antigens were also illustrated. Through reviewing the state-of-art in biomimetic particles, the lesson learnt from the natural traits and pathogenic invasion may shed light on the rational design for the enhanced vaccinations. 漏 2021 Elsevier B.V. |
| 学科主题 | Vaccines |
| 出版者 | Elsevier B.V. |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/60281]  |
| 作者单位 | 1.University of Chinese Academy of Sciences, Beijing, China 2.Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu; Gunma, Japan 3.State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Wu, Sihua,Xia, Yufei,Hu, Yuning,et al. Bio-mimic particles for the enhanced vaccinations: Lessons learnt from the natural traits and pathogenic invasion[J]. Advanced Drug Delivery Reviews,2021,176. |
| APA | Wu, Sihua,Xia, Yufei,Hu, Yuning,&Ma, Guanghui.(2021).Bio-mimic particles for the enhanced vaccinations: Lessons learnt from the natural traits and pathogenic invasion.Advanced Drug Delivery Reviews,176. |
| MLA | Wu, Sihua,et al."Bio-mimic particles for the enhanced vaccinations: Lessons learnt from the natural traits and pathogenic invasion".Advanced Drug Delivery Reviews 176(2021). |
入库方式： OAI收割
来源：过程工程研究所
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