Prophylactic vaccine delivery systems against epidemic infectious diseases
文献类型：期刊论文
| 作者 | Pan, Chao2; Yue, Hua1,3; Zhu, Li2; Ma, Guang-hui1,3; Wang, Heng-liang2 |
| 刊名 | Advanced Drug Delivery Reviews
 |
| 出版日期 | 2021-09-01 |
| 卷号 | 176 |
| 关键词 | Efficiency - Diseases - Viruses |
| ISSN号 | 0169409X |
| DOI | 10.1016/j.addr.2021.113867 |
| 英文摘要 | Prophylactic vaccines have evolved from traditional whole-cell vaccines to safer subunit vaccines. However, subunit vaccines still face problems, such as poor immunogenicity and low efficiency, while traditional adjuvants are usually unable to meet specific response needs. Advanced delivery vectors are important to overcome these barriers; they have favorable safety and effectiveness, tunable properties, precise location, and immunomodulatory capabilities. Nevertheless, there has been no systematic summary of the delivery systems to cover a wide range of infectious pathogens. We herein summarized and compared the delivery systems for major or epidemic infectious diseases caused by bacteria, viruses, fungi, and parasites. We also included the newly licensed vaccines (e.g., COVID-19 vaccines) and those close to licensure. Furthermore, we highlighted advanced delivery systems with high efficiency, cross-protection, or long-term protection against epidemic pathogens, and we put forward prospects and thoughts on the development of future prophylactic vaccines. 漏 2021 The Authors |
| 学科主题 | Vaccines |
| 项目编号 | This review was supported by the National Natural Science Foundation of China (No. 81930122, U20A20361, 32030062) and Beijing Municipal Natural Science Foundation (No. 2202056). We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript. |
| 出版者 | Elsevier B.V. |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/60287]  |
| 作者单位 | 1.State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing; 100190, China 2.State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing; 100071, China 3.University of Chinese Academy of Sciences, Beijing; 100049, China |
| 推荐引用方式 GB/T 7714 | Pan, Chao,Yue, Hua,Zhu, Li,et al. Prophylactic vaccine delivery systems against epidemic infectious diseases[J]. Advanced Drug Delivery Reviews,2021,176. |
| APA | Pan, Chao,Yue, Hua,Zhu, Li,Ma, Guang-hui,&Wang, Heng-liang.(2021).Prophylactic vaccine delivery systems against epidemic infectious diseases.Advanced Drug Delivery Reviews,176. |
| MLA | Pan, Chao,et al."Prophylactic vaccine delivery systems against epidemic infectious diseases".Advanced Drug Delivery Reviews 176(2021). |
入库方式： OAI收割
来源：过程工程研究所
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