Inclusion complexes of cannabidiol with 尾-cyclodextrin and its derivative: Physicochemical properties, water solubility, and antioxidant activity
文献类型：期刊论文
| 作者 | Li, Hang1,2; Chang, Sen-Lin1,2; Chang, Tan-Ran1,2; You, Ying1; Wang, Xiao-Dong1; Wang, Li-Wei1; Yuan, Xiao-Fan1; Tan, Ming-Hui1,2; Wang, Pei-Dong1,2; Xu, Peng-Wei1,2 |
| 刊名 | Journal of Molecular Liquids
 |
| 出版日期 | 2021-07-15 |
| 卷号 | 334 |
| ISSN号 | 1677322 |
| 关键词 | Antioxidants - Solubility - Integrated circuits - Dissolution - Physicochemical properties - Thermodynamics - Efficiency - Free radicals |
| DOI | 10.1016/j.molliq.2021.116070 |
| 英文摘要 | Cannabidiol (CBD), which has a wide variety of biological activities, is one of the phytocannabinoids from Cannabis sativa L. However, due to the poor aqueous solubility, its applications in food, cosmetic, and pharmaceutical fields are limited. Moreover, the previous researches on the improvement in the solubility of CBD are rare. Cyclodextrins (CDs) are useful materials to improve the solubility of poorly water-soluble molecules. Therefore, this work was aimed to study the physicochemical properties, water solubility, and dissolution rate of the inclusion complexes of CBD with 尾-cyclodextrin (尾-CD) and 2, 6-di-O-methyl-尾-cyclodextrin (DM-尾-CD), and to determine the influence of complexation on the antioxidant activity of CBD. Job's plot and phase solubility study revealed that CBD formed inclusion complexes with 尾-CD and DM-尾-CD at a 1:1 stoichiometric ratio. The thermodynamics analysis demonstrated that the inclusion process was spontaneous and endothermic. Then, the inclusion complexes of CBD with 尾-CD or DM-尾-CD were prepared and characterized by PXRD, FT-IR, DSC, SEM, and 1H NMR. The loading efficiency (LE) of the two inclusion complexes was 20.4% and 17.7% respectively, while the complexation efficiency (CE) was 92.4% and 90.8% respectively. Moreover, the results of molecular docking further showed that CBD was encapsulated successfully. The results also displayed that the water solubility of CBD in CBD/尾-CD inclusion complex (IC) and CBD/DM-尾-CD IC was significantly increased to 0.395 and 14.118 渭g/mL, which was enhanced by 17-fold and 614-fold respectively at such a high LE, and the in vitro dissolution rate of CBD was also promoted after complexation. Besides, the antioxidant activity of CBD was improved after encapsulation with 尾-CD and DM-尾-CD. Significantly, the ABTS free radical scavenging ability of the two inclusion complexes was better than that of Vitamin C (Vc). 漏 2021 Elsevier B.V. |
| 学科主题 | Cyclodextrins |
| 项目编号 | This work was financially supported by Yunnan Hempmon Pharmaceutical Co., Ltd.This work was financially supported by Yunnan Hempmon Pharmaceutical Co. Ltd. |
| 出版者 | Elsevier B.V. |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/60304]  |
| 作者单位 | 1.Division of Bioresources and Health Product Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing; 100190, China 2.School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing; 100049, China 3.Yunnan Hempmon Pharmaceutical Co., Ltd, Kunming; 650032, China |
| 推荐引用方式 GB/T 7714 | Li, Hang,Chang, Sen-Lin,Chang, Tan-Ran,等. Inclusion complexes of cannabidiol with 尾-cyclodextrin and its derivative: Physicochemical properties, water solubility, and antioxidant activity[J]. Journal of Molecular Liquids,2021,334. |
| APA | Li, Hang.,Chang, Sen-Lin.,Chang, Tan-Ran.,You, Ying.,Wang, Xiao-Dong.,...&Zhao, Bing.(2021).Inclusion complexes of cannabidiol with 尾-cyclodextrin and its derivative: Physicochemical properties, water solubility, and antioxidant activity.Journal of Molecular Liquids,334. |
| MLA | Li, Hang,et al."Inclusion complexes of cannabidiol with 尾-cyclodextrin and its derivative: Physicochemical properties, water solubility, and antioxidant activity".Journal of Molecular Liquids 334(2021). |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。