Experimental and theoretical explorations of nanocarriers' multistep delivery performance for rational design and anticancer prediction
文献类型：期刊论文
| 作者 | Bao, Weier2,3; Tian, Falin1; Lyu, Chengliang3; Liu, Bin2; Li, Bin1; Zhang, Luyao1; Liu, Xianwu2,3; Li, Feng3; Li, Dan2; Gao, Xiaoyong3 |
| 刊名 | Science Advances
 |
| 出版日期 | 2021-02-05 |
| 卷号 | 7期号:6 |
| 关键词 | Rigidity - Cardiovascular system |
| DOI | 10.1126/sciadv.aba2458 |
| 英文摘要 | The poor understanding of the complex multistep process taken by nanocarriers during the delivery process limits the delivery efficiencies and further hinders the translation of these systems into medicine. Here, we describe a series of six self-assembled nanocarrier types with systematically altered physical properties including size, shape, and rigidity, as well as both in vitro and in vivo analyses of their performance in blood circulation, tumor penetration, cancer cell uptake, and anticancer efficacy. We also developed both data and simulation-based models for understanding the influence of physical properties, both individually and considered together, on each delivery step and overall delivery process. Thus, beyond finding that nanocarriers that are simultaneously endowed with tubular shape, short length, and low rigidity outperformed the other types, we now have a suit of theoretical models that can predict how nanocarrier properties will individually and collectively perform in the multistep delivery of anticancer therapies. Copyright 漏 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). |
| 学科主题 | Physical Properties |
| 项目编号 | The financial supports from the National Natural Science Foundation of China (nos. 21622608, 31471577, 31772014, 11422215, 11272327, 11902092, and 11672079.), the National Key R&D Program of China (2017YFA0207900), the Beijing Nova Program (Z181100006218071), the Opening Fund of State Key Laboratory of Nonlinear Mechanics, and the China Postdoctoral Science Foundation (2019M650602) are acknowledged. We also appreciate the support in computation experiments from the Supercomputing Center of Chinese Academy of Sciences and Computing Center of National Center for Nanoscience and Technology. |
| 出版者 | American Association for the Advancement of Science |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/60363]  |
| 作者单位 | 1.Laboratory of Theoretical and Computational Nanoscience, Chinese Academy of Sciences (CAS) Key Laboratory for Nanosystem and Hierarchy Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing; 100190, China 2.Key Laboratory of Precision Nutrition and Food Quality, Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing; 100083, China 3.State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing; 100190, China 4.University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing; 100049, China |
| 推荐引用方式 GB/T 7714 | Bao, Weier,Tian, Falin,Lyu, Chengliang,et al. Experimental and theoretical explorations of nanocarriers' multistep delivery performance for rational design and anticancer prediction[J]. Science Advances,2021,7(6). |
| APA | Bao, Weier.,Tian, Falin.,Lyu, Chengliang.,Liu, Bin.,Li, Bin.,...&Li, Yuan.(2021).Experimental and theoretical explorations of nanocarriers' multistep delivery performance for rational design and anticancer prediction.Science Advances,7(6). |
| MLA | Bao, Weier,et al."Experimental and theoretical explorations of nanocarriers' multistep delivery performance for rational design and anticancer prediction".Science Advances 7.6(2021). |
入库方式： OAI收割
来源：过程工程研究所
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