A synergistic therapeutic nano-eyedrop for dry eye disease based on ascorbic acid-coupled exosomes
文献类型：期刊论文
| 作者 | Ma, Fang1,4; Feng, Jing1,4; Liu, Xi5; Tian, Ying1,4; Wang, Wen-Jing1,2; Luan, Fu-Xiao1,4; Wang, Ying-Jie1,4; Yang, Wei-Qiang1,4; Bai, Jing-Yi3,4; Zhang, Yi-Quan1,4 |
| 刊名 | Nanoscale
 |
| 出版日期 | 2022-12-16 |
| 卷号 | 15期号:4页码:1890-1899 |
| ISSN号 | 20403364 |
| 关键词 | Cell culture - Gold nanoparticles - Pathology - Phospholipids - Stem cells |
| DOI | 10.1039/d2nr05178h |
| 英文摘要 | Dry eye disease (DED), a complex ocular surface disease with a high prevalence rate, is associated with corneal injury, excess oxidative stress and inflammation. Current therapeutic strategies, including artificial tears and anti-inflammatory agents, are unable to address all the deleterious factors or to achieve a clinical cure due to their temporary or side effects. Here, we prepared a multiple-functional eyedrop based on the deposition of gold nanoparticles (AuNPs) reduced by ascorbic acid (AA) onto the exosomal phospholipid membrane of mesenchymal stem cell (mExo)-derived exosomes in situ (mExo@AA). The therapeutic value of mExo@AA for DED was demonstrated in a mouse DED model. Combining the benefits of mExo and AA, mExo@AA effectively improves corneal epithelium recovery and anti-inflammation capacity, decreases corneal reactive oxygen species, and restores tear secretion without adverse effects. Thus, this study suggests that mExo@AA is effective and safe as a therapeutic agent for the treatment of DED. 漏 2023 The Royal Society of Chemistry. |
| 学科主题 | Ascorbic Acid |
| 项目编号 | This work was supported by the National Natural Science Foundation of China (82070948, 82101138, and 82101142), China Postdoctoral Science Foundation (2021M692250), Beijing Hospitals Authority's Ascent Plan (DFL20220301), Shunyi District Beijing Science and Technology Achievements Transformation Coordination and Service Platform" Construction Fund (SYGX202010) |
| 出版者 | Royal Society of Chemistry |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/61305]  |
| 作者单位 | 1.Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing; 100080, China 2.Department of Neurosurgery, Health Science Center, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen; 518035, China 3.Department of Ophthalmology, Beijing Huairou Hospital, Capital Medical University, Beijing; 101400, China 4.Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing; 100020, China 5.Research Center for Tissue Repair and Regeneration, the Medical Innovation Research Department and 4th Medical Center, PLA General Hospital, PLA Medical College, Beijing; 100048, China |
| 推荐引用方式 GB/T 7714 | Ma, Fang,Feng, Jing,Liu, Xi,et al. A synergistic therapeutic nano-eyedrop for dry eye disease based on ascorbic acid-coupled exosomes[J]. Nanoscale,2022,15(4):1890-1899. |
| APA | Ma, Fang.,Feng, Jing.,Liu, Xi.,Tian, Ying.,Wang, Wen-Jing.,...&Tao, Yong.(2022).A synergistic therapeutic nano-eyedrop for dry eye disease based on ascorbic acid-coupled exosomes.Nanoscale,15(4),1890-1899. |
| MLA | Ma, Fang,et al."A synergistic therapeutic nano-eyedrop for dry eye disease based on ascorbic acid-coupled exosomes".Nanoscale 15.4(2022):1890-1899. |
入库方式： OAI收割
来源：过程工程研究所
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