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Association between subclinical hypothyroidism and psychotic features in Chinese young adults with first-episode and untreated major depressive disorder

文献类型：期刊论文

作者Dai, Wenyu1; Liu, Jieyu1,2; Xie, Haiqing2; Teng, Ziwei1; Luo, Wenbo1; Yuan, Hui3; Chen, Jindong1; Liu, Minghui2; Zhang, Xiangyang4
刊名JOURNAL OF AFFECTIVE DISORDERS
出版日期2023-07-15
卷号333页码:209-215
ISSN号0165-0327
关键词Subclinical hypothyroidism Psychotic features Major depressive disorder Young adult
DOI10.1016/j.jad.2023.04.067
通讯作者Liu, Minghui(liuminghui03@aliyun.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Background: Thyroid dysfunction is often reported in patients with major depressive disorder (MDD) and may be associated with depression severity and psychotic symptoms. We included young adults with first-episode and untreated MDD to avoid the effect of age and disease duration on thyroid dysfunction and psychotic symptoms. Methods: 481 young patients with MDD (aged 18-24 years) were recruited. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Positive and Negative Syndrome Scale (PANSS) positive subscale and Global Impression of Severity Scale (CGI-S) were used to assess depression, anxiety, psychotic symptoms and disease severity, respectively. Results: The prevalence rate of subclinical hypothyroidism (SCH) and thyroid antibody positivity was 56.76 % (273/481) and 26.61 % (128/481) in young MDD, respectively. A higher proportion of MDD patients with SCH displayed psychotic features (14.3 % vs. 5.3 %, OR = 2.985, p = 0.001). TSH was a risk factor for psychotic symptoms in MDD patient with SCH (B = 0.136, p = 0.017, OR = 1.384), with an AUC of 0.709, indicating acceptable discrimination. Multivariate regression analysis also showed that TSH was also independently asso-ciated with PANSS positive score (B = 0.339, t = 2.019, p = 0.045). Limitation: This cross-sectional study design did not demonstrate a causal relationship. Relying solely on the PANSS positive subscale as psychotic symptoms may cause bias. Conclusions: Our findings suggest that SCH is common in young patients with first-episode and untreated MDD. MDD patients with higher TSH levels may suffer from more psychotic symptoms. Regular screening of serum thyroid hormones is necessary in patients with MDD.
收录类别SCI
WOS关键词THYROID-HORMONE ; ANXIETY ; PREVALENCE ; RISK ; SCHIZOPHRENIA ; POPULATION ; DELUSIONS ; SEVERITY ; SYMPTOMS ; ILLNESS
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
出版者ELSEVIER
WOS记录号WOS:000988588300001
源URL[http://ir.psych.ac.cn/handle/311026/45355]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Liu, Minghui; Zhang, Xiangyang
作者单位1.Cent South Univ, Xiangya Hosp 2, China Natl Technol Inst Mental Disorders, Natl Clin Res Ctr Mental Disorders,Dept Psychiat, Changsha 410011, Hunan, Peoples R China
2.Cent South Univ, Xiangya Hosp 2, Dept Ultrasound Diagnost, Changsha 410011, Hunan, Peoples R China
3.Cent South Univ, Xiangya Hosp 2, Dept Stomatol, Changsha 410011, Hunan, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Dai, Wenyu,Liu, Jieyu,Xie, Haiqing,et al. Association between subclinical hypothyroidism and psychotic features in Chinese young adults with first-episode and untreated major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2023,333:209-215.
APA Dai, Wenyu.,Liu, Jieyu.,Xie, Haiqing.,Teng, Ziwei.,Luo, Wenbo.,...&Zhang, Xiangyang.(2023).Association between subclinical hypothyroidism and psychotic features in Chinese young adults with first-episode and untreated major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,333,209-215.
MLA Dai, Wenyu,et al."Association between subclinical hypothyroidism and psychotic features in Chinese young adults with first-episode and untreated major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 333(2023):209-215.

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来源：心理研究所

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