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Prevalence and risk factors of psychotic symptoms in middle-aged patients with first-episode drug-naive major depressive disorder: A large-scale cross-sectional study

文献类型：期刊论文

作者Liu, Shilin1; Lin, Keyi2,3; Zhang, Yang4; Gao, Yaotian2,3; Wang, Wei4; Du, Mengcheng4; Jiang, Tao2,3,4,5; Zhou, Min1; Zhang, Xiangyang6,7
刊名JOURNAL OF AFFECTIVE DISORDERS
出版日期2023-03-15
卷号325页码:102-109
ISSN号0165-0327
关键词Major depressive disorder Psychotic major depression Clinical correlates Cross-sectional study Middle-aged
DOI10.1016/j.jad.2023.01.002
通讯作者Jiang, Tao(jiangtao_aysfy@163.com) ; Zhou, Min(dminzhou@ustc.edu.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Background: Psychotic symptoms are common in patients with major depressive disorder (MDD). However, few studies have assessed the incidence of comorbid psychotic symptoms in first-episode drug naive (FEDN) MDD patients. The present study aimed to evaluate the prevalence and risk factors of psychotic symptoms in a large sample of middle-aged Chinese patients with FEDN MDD. Methods: 813 middle-aged (age range 35 to 65 years) outpatients with FEDN MDD were recruited. The 17-item Hamilton Rating Scale for Depression (HAMD), the 14-item Hamilton Anxiety Rating Scale (HAMA), and the positive subscales of the Positive and Negative Syndrome Scale (PANSS) were used to assess patient anxiety, depression and psychotic symptoms, respectively. Results: The prevalence of psychotic symptoms in middle-aged patients with FEND MDD was 10.95 %. Multi-variate logistic regression analysis showed that HAMA score, HAMD score, TSH, TC and BMI levels were sig-nificant predictors of psychotic symptoms in MDD middle-aged patients. The HAMA score and HAMD score predicted psychotic symptoms for both male and female middle-aged patients with MDD, while higher TSH, TC and BMI levels were correlated with psychotic symptoms only in female MDD patients. Furthermore, combining the HAMA score, HAMD score, and TSH could differentiate between psychotic major depression (PMD) and nonpsychotic major depression (NPMD) in middle-aged patients. Conclusions: Psychotic symptoms among middle-aged patients with MDD can be identified by integrating clinical and biological variables as early as possible during the first time see a doctor.
收录类别SCI
WOS关键词RATING-SCALE ; ANXIETY ; FEATURES ; OBESITY ; ONSET ; SCHIZOPHRENIA ; DELUSIONS ; PATTERNS ; GLUCOSE ; STIGMA
资助项目Research Fund of Anhui Institute of Translational Medicine[2021zhyx-C72] ; National Key R D Program[2021YFE0100100]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
出版者ELSEVIER
WOS记录号WOS:000990039900001
资助机构Research Fund of Anhui Institute of Translational Medicine ; National Key R D Program
源URL[http://ir.psych.ac.cn/handle/311026/45361]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Jiang, Tao; Zhou, Min; Zhang, Xiangyang
作者单位1.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Neurocrit Care Unit, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China
2.Anhui Med Univ, Affiliated Hosp 1, Dept Neurosurg, Hefei 230001, Anhui, Peoples R China
3.Anhui Publ Hlth Clin Ctr, Hefei 230001, Anhui, Peoples R China
4.Anhui Med Univ, Affiliated Hosp 2, Dept Neurosurg, Hefei 230001, Anhui, Peoples R China
5.Anhui Prov Inst Translat Med, Hefei 230001, Anhui, Peoples R China
6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
7.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Shilin,Lin, Keyi,Zhang, Yang,et al. Prevalence and risk factors of psychotic symptoms in middle-aged patients with first-episode drug-naive major depressive disorder: A large-scale cross-sectional study[J]. JOURNAL OF AFFECTIVE DISORDERS,2023,325:102-109.
APA Liu, Shilin.,Lin, Keyi.,Zhang, Yang.,Gao, Yaotian.,Wang, Wei.,...&Zhang, Xiangyang.(2023).Prevalence and risk factors of psychotic symptoms in middle-aged patients with first-episode drug-naive major depressive disorder: A large-scale cross-sectional study.JOURNAL OF AFFECTIVE DISORDERS,325,102-109.
MLA Liu, Shilin,et al."Prevalence and risk factors of psychotic symptoms in middle-aged patients with first-episode drug-naive major depressive disorder: A large-scale cross-sectional study".JOURNAL OF AFFECTIVE DISORDERS 325(2023):102-109.

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来源：心理研究所

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