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Sex differences in the association between suicidal ideation and neurocognitive function in Chinese patients with schizophrenia

文献类型：期刊论文

作者Wu, Fengchun1,2,3; Yi, Yun1,4; Lian, Yunling5; Chen, Qiang4; Luo, Lanfang4; Yang, Hanlun6; Li, Hehua1; Feng, Yangdong1; Feng, Shixuan1; Zhou, Sumiao1
刊名EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
出版日期2023-05-15
页码9
关键词Sex difference Suicidal ideation Neurocognitive function RBANS
ISSN号0940-1334
DOI10.1007/s00406-023-01616-8
通讯作者Huang, Yuanyuan(13602480297@163.com) ; Li, Zezhi(biolpsychiatry@126.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要There is increasing evidence that sex differences exist in many clinical manifestations of patients with schizophrenia, including suicidal ideation (SI) and neurocognitive function. The present study was performed to explore the sex differences in the association between SI and neurocognitive function in Chinese patients with schizophrenia. A total of 1188 inpatients with schizophrenia were recruited from multicenter psychiatric hospitals. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was utilized to evaluate the neurocognitive function of all patients. The Positive and Negative Syndrome Scale (PANSS) was utilized to assess the psychopathology of patients. The Beck Scale for Suicide Ideation (BSSI) was used to assess the severity of SI. In male patients, the suicide risk score was significantly associated with PANSS negative symptoms (r = 0.167, p = 0.043), visuospatial subscale (r = - 0.261, p = 0.001), and RBANS total scores (r = - 0.172, p = 0.037). Furthermore, multivariate linear regression analysis showed that the visuospatial subscale (beta = - 0.490, t = - 3.273, p = 0.001) was independently associated with the suicide risk score in male patients. In female patients, the suicide risk score was significantly correlated with PANSS positive symptoms (r = 0.249, p = 0.021), negative symptoms (r = 0.394, p < 0.001), general psychopathology (r = 0.276, p = 0.01) and PANSS total score (r = 0.365, p = 0.001). Multivariate linear regression analysis showed that PANSS negative symptoms (beta = 1.849, t = 3.933, p = 0.001) were significantly associated with suicide risk scores in female patients. Our findings indicate that there are sex differences in the association between SI and neurocognitive function in patients with schizophrenia. Based on the findings of our study, gender-specific prevention and intervention strategies may make a difference in reducing SI in Chinese schizophrenia patients.
收录类别SCI
WOS关键词COGNITIVE FUNCTION ; EXECUTIVE FUNCTION ; SELF-STIGMA ; MORTALITY ; TESTOSTERONE ; INSIGHT ; MEMORY ; PERFORMANCE ; SYMPTOMS ; BRAIN
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:000987898400001
出版者SPRINGER HEIDELBERG
源URL[http://ir.psych.ac.cn/handle/311026/45371]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Huang, Yuanyuan; Li, Zezhi; Zhang, Xiangyang
作者单位1.Guangzhou Med Univ, Dept Psychiat, Affiliated Brain Hosp, 36 Mingxin Rd, Guangzhou 510370, Peoples R China
2.Guangdong Engn Technol Res Ctr Translat Med Mental, Guangzhou, Peoples R China
3.Guangzhou Med Univ, Key Lab Neurogenet & Channelopathies Guangdong Pro, Minist Educ China, Guangzhou, Peoples R China
4.Guangxi Zhuang Autonomous Reg, Dept Psychiat, Brain Hosp, Guangxi, Peoples R China
5.Qingdao Mental Hlth Ctr, Dept Psychiat, Qingdao, Peoples R China
6.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou, Peoples R China
7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Fengchun,Yi, Yun,Lian, Yunling,et al. Sex differences in the association between suicidal ideation and neurocognitive function in Chinese patients with schizophrenia[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2023:9.
APA Wu, Fengchun.,Yi, Yun.,Lian, Yunling.,Chen, Qiang.,Luo, Lanfang.,...&Zhang, Xiangyang.(2023).Sex differences in the association between suicidal ideation and neurocognitive function in Chinese patients with schizophrenia.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,9.
MLA Wu, Fengchun,et al."Sex differences in the association between suicidal ideation and neurocognitive function in Chinese patients with schizophrenia".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2023):9.

入库方式： OAI收割

来源：心理研究所

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