Effect of HD-tDCS on white matter integrity and associated cognitive function in chronic schizophrenia: A double-blind, sham-controlled randomized trial
文献类型：期刊论文
| 作者 | Xu, Hui1,2,4; Zhou, Yongjie3; Wang, Jiesi5 ; Liang, Zhen6; Wang, Yang7; Wu, Weibin8; Liu, Yiliang8; Liu, Xia3; Zhang, Xin3; Huo, Lijuan1,2,9
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| 刊名 | PSYCHIATRY RESEARCH
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| 出版日期 | 2023-06-01 |
| 卷号 | 324页码:9 |
| ISSN号 | 0165-1781 |
| 关键词 | High-definition transcranial direct current stimulation Randomized controlled trial Schizophrenia Cognitve deficits Diffusion tensor imaging |
| DOI | 10.1016/j.psychres.2023.115183 |
| 通讯作者 | Huo, Lijuan(lijuan.huo@m.scnu.edu.cn) |
| 英文摘要 | Schizophrenia is a disabling major mental disorder, which includes critical deficits in cognitive function, for which no effective intervention currently exists. The aim of our double-blind, randomized, sham-controlled trial was to evaluate the effects of high-definition transcranial direct current stimulation (HD-tDCS) on the cognitive deficits in schizophrenia. This study sample consisted of 56 individuals with chronic schizophrenia, randomly allocated to either the active stimulation or sham group. The treatment consisted of ten consecutive days of HDtDCS, 20 min/day, applied over the left dorsolateral prefrontal lobe. Changes in clinical outcomes, cognitive assessments, and diffusion tensor imaging were evaluated pre- to post-intervention. Matched-healthy controls (HCs) were included to identify white matter changes in patients with schizophrenia before treatment. Compared to HCs, schizophrenia was associated with reduced integrity of the white matter tracts of the corpus callosum and corona radiata. HD-tDCS enhanced integrity in the corpus callosum and anterior and superior corona radiata, which was associated with the change in cognitive performance. HD-tDCS offers a potential approach to improve cognition deficits in schizophrenia through a modulatory effect on white matter tracts. Given the lack of approved treatments for cognitive deficits, these findings are clinically relevant. |
| 收录类别 | SCI |
| WOS关键词 | DIRECT-CURRENT STIMULATION ; BRAIN-STIMULATION ; NEGATIVE SYMPTOMS ; PLASTICITY ; DEFICITS ; CONNECTIVITY ; IMPAIRMENTS ; TASKS ; SCALE |
| 资助项目 | National Natural Science Founda- tion of China[82102673] ; Natural Science Foundation of Guang- dong Province[2023A1515011802] ; Guangzhou Science and Technology Project[202201011336] ; Shenzhen Science and Technology Project[JCYJ20210324135610029] ; Sanming Project of Medicine in Shenzhen ; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties[SZGSP013] ; Shenzhen Key Medical Discipline Construction Fund[SZXK072] ; Shenzhen Science and technology research and Development Fund for Sustainable development project[KCXFZ20201221173613036] |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| 出版者 | ELSEVIER IRELAND LTD |
| WOS记录号 | WOS:000978779900001 |
| 资助机构 | National Natural Science Founda- tion of China ; Natural Science Foundation of Guang- dong Province ; Guangzhou Science and Technology Project ; Shenzhen Science and Technology Project ; Sanming Project of Medicine in Shenzhen ; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties ; Shenzhen Key Medical Discipline Construction Fund ; Shenzhen Science and technology research and Development Fund for Sustainable development project |
| 源URL | [http://ir.psych.ac.cn/handle/311026/45383]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Huo, Lijuan |
| 作者单位 | 1.South China Normal Univ, Inst Brain Res & Rehabil, Key Lab Brain Cognit & Educ Sci, Minist Educ, Guangzhou, Peoples R China 2.South China Normal Univ, Guangdong Key Lab Mental Hlth & Cognit Sci, Guangzhou, Peoples R China 3.Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Shenzhen, Peoples R China 4.McMaster Univ, Peter Boris Ctr Addict Res, Hamilton, ON, Canada 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 6.Shenzhen Univ, Hlth Sci Ctr, Sch Biomed Engn, Guangdong Prov Key Lab Biomed Measurements & Ultr, Shenzhen, Peoples R China 7.Shenzhen Univ, Coll Management, Shenzhen, Peoples R China 8.Third Peoples Hosp Foshan, Foshan, Peoples R China 9.Guangzhou Med Univ, Affiliated Brain Hosp, Dept Psychiat, Guangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Hui,Zhou, Yongjie,Wang, Jiesi,et al. Effect of HD-tDCS on white matter integrity and associated cognitive function in chronic schizophrenia: A double-blind, sham-controlled randomized trial[J]. PSYCHIATRY RESEARCH,2023,324:9. |
| APA | Xu, Hui.,Zhou, Yongjie.,Wang, Jiesi.,Liang, Zhen.,Wang, Yang.,...&Huo, Lijuan.(2023).Effect of HD-tDCS on white matter integrity and associated cognitive function in chronic schizophrenia: A double-blind, sham-controlled randomized trial.PSYCHIATRY RESEARCH,324,9. |
| MLA | Xu, Hui,et al."Effect of HD-tDCS on white matter integrity and associated cognitive function in chronic schizophrenia: A double-blind, sham-controlled randomized trial".PSYCHIATRY RESEARCH 324(2023):9. |
入库方式： OAI收割
来源：心理研究所
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