Association between thyroid autoimmunity and clinical characteristics in first-episode and drug-naive depressed patients with suicide attempts
文献类型：期刊论文
| 作者 | Feng, Xue-Zhu1,2,3; Wang, Ke1,2,4; Li, Zhe1,2; Wang, Fei1,2,5; Li, Zi-Yi6; Tan, Xuan1,2,3; Zhu, Wei-Li1,2; Zhang, Xiang-Yang7,8,9 ; Li, Su-Xia1,2,10
|
| 刊名 | GENERAL HOSPITAL PSYCHIATRY
 |
| 出版日期 | 2023-07-01 |
| 卷号 | 83页码:156-163 |
| ISSN号 | 0163-8343 |
| 关键词 | Major depressive disorder Thyroid autoimmunity Thyroid autoantibody Suicide attempt Psychotic positive symptoms |
| DOI | 10.1016/j.genhosppsych.2023.05.008 |
| 通讯作者 | Zhang, Xiang-Yang(zhangxy@psych.ac.cn) ; Li, Su-Xia(li313@bjmu.edu.cn) |
| 英文摘要 | Background: Previous reports had linked depression to thyroid function. However, the relationship between thyroid function and clinical characteristics in major depressive disorder (MDD) patients with suicidal attempts (SA) is still unclear. Aims: This study aims to reveal the association between thyroid autoimmunity and clinical characteristics in depressed patients with SA. Methods: We divided 1718 first-episode and drug-naive MDD patients into groups with suicide attempt (MDD-SA) and without suicide attempt (MDD-NSA). Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), and the positive subscale of the Positive and Negative Syndrome Scale (PANSS) were assessed; thyroid function and autoantibodies were detected. Results: The total scores of HAMD, HAMA and psychotic positive symptoms were significantly higher in patients with MDD-SA, accompanied by higher levels of TSH, TG-Ab and TPO-Ab, than in patients with MDD-NSA, without gender differences. Total scores of positive symptoms (TSPS) in MDD-SA patients with increased TSH or TG-Ab was significantly higher than in MDD-NSA patients and in MDD-SA patients with normal TSH and TG-Ab. The proportion of elevated-TSPS in MDD-SA patients was >4 times that in MDD-NSA patients. The pro-portion of MDD-SA patients with elevated-TSPS was >3 times that with not-elevated TSPS patients. Conclusions: Thyroid autoimmune abnormalities and psychotic positive symptoms may be the clinical features of MDD-SA patients. Psychiatrists should be more alert to the possibility of suicidal behaviors when they first encounter such a patient. |
| 收录类别 | SCI |
| WOS关键词 | TOWER-OF-BABEL ; RISK ; HYPOTHYROIDISM ; AUTOANTIBODIES ; THYROGLOBULIN ; NOMENCLATURE ; PREVALENCE ; DISORDER ; BEHAVIOR ; DISEASE |
| 资助项目 | National Natural Science Foundation of China[81871071] ; Beijing Municipal Natural Science Foundation[7222109] ; National Clinical Research Centre for Mental Disorder (Peking University Sixth Hospital) , the Key Research Project of Independent Exploration in 2021[NCRC2021Z03] |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE INC |
| WOS记录号 | WOS:000999144400001 |
| 资助机构 | National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; National Clinical Research Centre for Mental Disorder (Peking University Sixth Hospital) , the Key Research Project of Independent Exploration in 2021 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/45403]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Xiang-Yang; Li, Su-Xia |
| 作者单位 | 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China 2.Peking Univ, Beijing Key Lab Drug Dependence Res, Beijing 100191, Peoples R China 3.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 100191, Peoples R China 4.Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Beijing 100191, Peoples R China 5.Shanxi Med Univ, Clin Med Coll 1, Taiyuan 030001, Peoples R China 6.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Translat Med Ctr, Key Lab Endocrinol,Natl Hlth Commiss,Dept Endocrin, Beijing 100005, Peoples R China 7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 8.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China 9.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth,Dept Psychol, Yard 16,Lincui Rd, Beijing 100101, Peoples R China 10.Peking Univ, Natl Inst Drug Dependence, 38 Xue Yuan Rd, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Xue-Zhu,Wang, Ke,Li, Zhe,et al. Association between thyroid autoimmunity and clinical characteristics in first-episode and drug-naive depressed patients with suicide attempts[J]. GENERAL HOSPITAL PSYCHIATRY,2023,83:156-163. |
| APA | Feng, Xue-Zhu.,Wang, Ke.,Li, Zhe.,Wang, Fei.,Li, Zi-Yi.,...&Li, Su-Xia.(2023).Association between thyroid autoimmunity and clinical characteristics in first-episode and drug-naive depressed patients with suicide attempts.GENERAL HOSPITAL PSYCHIATRY,83,156-163. |
| MLA | Feng, Xue-Zhu,et al."Association between thyroid autoimmunity and clinical characteristics in first-episode and drug-naive depressed patients with suicide attempts".GENERAL HOSPITAL PSYCHIATRY 83(2023):156-163. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。