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Prevalence and clinical correlates of abnormal lipid metabolism in first-episode and drug-naive patients with major depressive disorder with abnormal glucose metabolism

文献类型：期刊论文

作者Zhu, Quanfeng1; Jiang, Guojun1; Lang, XiaoE2; Fu, Zhengchuang1; Zhang, Peng1; Zheng, Yali1; Zhang, Xiangyang3,4
刊名SCIENTIFIC REPORTS
出版日期2023-05-18
卷号13期号:1页码:8
ISSN号2045-2322
DOI10.1038/s41598-023-35290-6
通讯作者Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Comorbid glucose metabolism abnormalities are very common in patients with major depressive disorder (MDD), and glucose metabolism and lipid metabolism are closely related. However, there are few researches on the incidence and related factors of lipid metabolism abnormalities among MDD patients with comorbid glucose metabolism abnormalities. A cross-sectional study involving 1718 first-episode and drug-naive (FEDN) MDD patients was conducted. The 17-item Hamilton Depression Scale (HAMD-17), Hamilton Anxiety Rating Scale (HAMA) and Positive and Negative Syndrome Scale (PANSS) positive subscale were utilized to evaluate depressive, anxiety and psychotic symptom, respectively. Serum thyroid function-related parameters, glucose- and lipid-metabolism parameters were measured. The prevalence of abnormal lipid metabolism was significantly higher in FEDN MDD patients with abnormal glucose metabolism than in those without abnormal glucose metabolism (P < 0.001). In MDD patients with abnormal glucose metabolism, TSH, FT3 and body mass index (BMI) levels were significantly higher in the abnormal lipid metabolism subgroup than in the non-abnormal lipid metabolism subgroup. Binary logistic regression analysis showed that TSH, FT3 and BMI were the influencing factors of abnormal lipid metabolism in MDD patients with abnormal glucose metabolism (all P < 0.05). MDD patients with abnormal glucose metabolism have a high prevalence of abnormal lipid metabolism. Moreover, abnormal glucose metabolism was an independent risk factor for abnormal lipid metabolism in patients with MDD. In addition, thyroid hormone function and BMI may contribute to the co-occurrence of abnormal lipid metabolism in MDD patients with abnormal glucose metabolism.
收录类别SCI
WOS关键词ASSOCIATION ; CHOLESTEROL ; RECEPTOR
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000992525500014
出版者NATURE PORTFOLIO
源URL[http://ir.psych.ac.cn/handle/311026/45416]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang, Xiangyang
作者单位1.Hangzhou Normal Univ, Affiliated Xiaoshan Hosp, Hangzhou, Peoples R China
2.Shanxi Med Univ, Hosp 1, Clin Med Coll 1, Dept Psychiat, Taiyuan, Peoples R China
3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Quanfeng,Jiang, Guojun,Lang, XiaoE,et al. Prevalence and clinical correlates of abnormal lipid metabolism in first-episode and drug-naive patients with major depressive disorder with abnormal glucose metabolism[J]. SCIENTIFIC REPORTS,2023,13(1):8.
APA Zhu, Quanfeng.,Jiang, Guojun.,Lang, XiaoE.,Fu, Zhengchuang.,Zhang, Peng.,...&Zhang, Xiangyang.(2023).Prevalence and clinical correlates of abnormal lipid metabolism in first-episode and drug-naive patients with major depressive disorder with abnormal glucose metabolism.SCIENTIFIC REPORTS,13(1),8.
MLA Zhu, Quanfeng,et al."Prevalence and clinical correlates of abnormal lipid metabolism in first-episode and drug-naive patients with major depressive disorder with abnormal glucose metabolism".SCIENTIFIC REPORTS 13.1(2023):8.

入库方式： OAI收割

来源：心理研究所

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