Prevalence and clinical correlates of abnormal glucose metabolism in young, first- episode and medication-naive outpatients with major depressive disorder
文献类型：期刊论文
| 作者 | Chen, Yi-Huan1; Wang, Hua-Ning1; Lang, Xiao-E2; Zhang, Xiang -Yang3,4
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| 刊名 | PSYCHIATRY RESEARCH
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| 出版日期 | 2023-07-01 |
| 卷号 | 325页码:8 |
| 关键词 | Abnormal glucose metabolism Medication -naive Major depressive disorder Young First-episode |
| ISSN号 | 0165-1781 |
| DOI | 10.1016/j.psychres.2023.115250 |
| 通讯作者 | Zhang, Xiang -Yang(zhangxy@psych.ac.cn) |
| 英文摘要 | Backgrounds: The high co-morbidity of abnormal glucose metabolism in depressed patients has been extensively studied, but few studies have explored abnormal glucose metabolism in young patients with major depressive disorder (MDD). This study aimed to examine the prevalence and clinical correlates of abnormal glucose metabolism in young patients with first-episode medication-naive (FEMN) MDD.Methods: A cross-sectional study was conducted on 1289 young Chinese outpatients with FEMN MDD. All sub-jects were assessed on the Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale (HAMA), Positive and Negative Syndrome Scale, and their sociodemographic information was collected, and blood pressure, blood glucose, lipid and thyroid hormone levels were measured. Results: The prevalence of abnormal glucose metabolism was 12.57% in young FEMN MDD outpatients. Thyroid stimulating hormone (TSH) levels and HAMA scale scores were associated with fasting blood glucose levels in patients with FEMN MDD (P<0.05), and TSH could differentiate patients with abnormal normal glucose meta-bolism from those without abnormal glucose metabolism (Area Under Curve of 0.774).Conclusions: Our study showed a high prevalence of comorbid glucose metabolism abnormalities in young FEMN MDD outpatients. TSH may be a promising biomarker of abnormal glucose metabolism in young patients with FEMN MDD. |
| 收录类别 | SCI |
| WOS关键词 | RISK-FACTORS ; DIABETES-MELLITUS ; SCALE ; ANTIDEPRESSANTS ; DYSFUNCTION ; DIAGNOSIS ; ANXIETY ; PEOPLE ; ADULTS |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000998439700001 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://ir.psych.ac.cn/handle/311026/45437]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Xiang -Yang |
| 作者单位 | 1.Air Force Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian, Peoples R China 2.Shanxi Med Univ, Hosp 1, Dept Psychiat, Taiyuan, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yi-Huan,Wang, Hua-Ning,Lang, Xiao-E,et al. Prevalence and clinical correlates of abnormal glucose metabolism in young, first- episode and medication-naive outpatients with major depressive disorder[J]. PSYCHIATRY RESEARCH,2023,325:8. |
| APA | Chen, Yi-Huan,Wang, Hua-Ning,Lang, Xiao-E,&Zhang, Xiang -Yang.(2023).Prevalence and clinical correlates of abnormal glucose metabolism in young, first- episode and medication-naive outpatients with major depressive disorder.PSYCHIATRY RESEARCH,325,8. |
| MLA | Chen, Yi-Huan,et al."Prevalence and clinical correlates of abnormal glucose metabolism in young, first- episode and medication-naive outpatients with major depressive disorder".PSYCHIATRY RESEARCH 325(2023):8. |
入库方式： OAI收割
来源：心理研究所
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