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Interactions between genetic variants and environmental risk factors are associated with the severity of pelvic organ prolapse

文献类型：期刊论文

作者Li, Lei1; Zhao, Guangyi2,3; Wu, Jie4; Pang, Haiyu5; Zhang, Tianli6; Chen, Juan1; Zhang, Kunlin2,3,8; Zhu, Lan1,7
刊名MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
出版日期2023-06-01
卷号30期号:6页码:621-628
ISSN号1072-3714
关键词Age Genexenvironment interaction Maximum birth weight Pelvic organ prolapse Single-nucleotide polymorphism
DOI10.1097/GME.0000000000002182
通讯作者Zhang, Kunlin(zhangkl@psych.ac.cn) ; Zhu, Lan(zhu_julie@vip.sina.com)
英文摘要ObjectiveBoth environmental and genetic risk factors contribute to pelvic organ prolapse (POP). No genome-wide study has investigated the gene-environment (G x E) interactions. In this study, we aim to identify single nucleotide polymorphisms (SNPs) that may interact with the potential environmental factors, maximum birth weight, and age in Chinese women.MethodsWe recruited 576 women for phase 1 and 264 women for phase 2 with stages III and IV prolapse from six geographic regions of China. Genomic DNAs from blood samples were genotyped using Affymetrix Axiom Genome-Wide CHB1 Array of 640,674 SNPs for phase 1 and Illumina Infinium Asian Screening Array of 743,722 SNPs for phase 2. Meta-analysis was used to combine the two results. Interactions of genetic variants with maximum birth weight and age on POP severity were identified.ResultsIn phase 1, 502,283 SNPs in 523 women passed quality control and 450 women had complete POP-quantification measurements. In phase 2, 463,351 SNPs in 257 women passed quality control with complete POP-quantification measurements. Three SNPs rs76662748 (WDR59, P-meta = 2.146 x 10(-8)), rs149541061 (3p26.1, P-meta = 9.273 x 10(-9)), and rs34503674 (DOCK9, P-meta = 1.778 x 10(-9)) respectively interacted with maximum birth weight, and two SNPs rs74065743 (LINC01343, P-meta = 4.386 x 10(-8)) and rs322376 (NEURL1B-DUSP1, P-meta = 2.263 x 10(-8)), respectively, interacted with age. The magnitude of disease severity associated with maximum birth weight and age differed according to genetic variants.ConclusionsThis study provided preliminary evidence that interactions between genetic variants and environmental risk factors are associated with POP severity, suggesting the potential use of combining epidemiologic exposure data with selected genotyping for risk assessment and patient stratification.
收录类别SCI
WOS关键词STRESS URINARY-INCONTINENCE ; BIRTH
资助项目National Key R&D Program of China[2018YFC2002201] ; National Natural Science Foundation of China[81830043] ; National Natural Science Foundation of China[82171621] ; National Natural Science Foundation of China[82174237] ; National High Level Hospital Clinical Research Funding[2022-PUMCH-A-231] ; Chinese government via the 12th Five-Year Plan National Project[2014BAI05B02]
WOS研究方向Obstetrics & Gynecology
语种英语
出版者LIPPINCOTT WILLIAMS & WILKINS
WOS记录号WOS:000999488000009
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; National High Level Hospital Clinical Research Funding ; Chinese government via the 12th Five-Year Plan National Project
源URL[http://ir.psych.ac.cn/handle/311026/45481]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang, Kunlin; Zhu, Lan
作者单位1.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Natl Clin Res Ctr Obstet & Gynecol Dis, Dept Obstet & Gynecol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Lab Med, Beijing, Peoples R China
5.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Med Sci Res Ctr, Beijing, Peoples R China
6.Nankai Univ, Coll Life Sci, Tianjin, Peoples R China
7.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, 1 Shuai Fu Yuan, Beijing 100730, Peoples R China
8.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Li, Lei,Zhao, Guangyi,Wu, Jie,et al. Interactions between genetic variants and environmental risk factors are associated with the severity of pelvic organ prolapse[J]. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY,2023,30(6):621-628.
APA Li, Lei.,Zhao, Guangyi.,Wu, Jie.,Pang, Haiyu.,Zhang, Tianli.,...&Zhu, Lan.(2023).Interactions between genetic variants and environmental risk factors are associated with the severity of pelvic organ prolapse.MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY,30(6),621-628.
MLA Li, Lei,et al."Interactions between genetic variants and environmental risk factors are associated with the severity of pelvic organ prolapse".MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 30.6(2023):621-628.

入库方式： OAI收割

来源：心理研究所

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