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Chronic social comparison elicits depression- and anxiety-like behaviors and alterations in brain-derived neurotrophic factor expression in male rats

文献类型：期刊论文

作者Xue, Bing1,3; Ma, Yin-Yan1,3; Zhu, Jie-Ying1,3; Mu, Yan1,3; Li, Yong-Hui1,3; Shen, Fang1,3; Liang, Jing1,3; Zhang, Jian-Jun1,2,3
刊名ANIMAL COGNITION
出版日期2023-06-11
页码15
ISSN号1435-9448
关键词Chronic social comparison Depression-like behaviors Anxiety-like behaviors BDNF mPFC Dorsal hippocampus
DOI10.1007/s10071-023-01798-7
通讯作者Zhang, Jian-Jun(zhangjj@psych.ac.cn)
英文摘要Social comparison is a fundamental human characteristic; however, long-term social comparison may induce psychological stress and can lead to depression and anxiety. Recent studies have shown that nonhuman primates compare themselves with others; however, no studies have investigated whether social comparisons exist among rodents. In the present study, we established a rat model of social comparison. This model was subsequently used to examine the effects of the differential environment of a partner on depression- and anxiety-like behaviors in male rats, as well as to assess the changes in serum, medial prefrontal cortex (mPFC), and dorsal hippocampus brain-derived neurotrophic factor (BDNF) levels induced by long-term social comparison. Compared to rats whose partners were exposed to the same environment, rats whose partners were exposed to two combined enriched environmental stimuli for 14 days showed significantly decreased social novelty preference and sucrose consumption. No anxiety-like behaviors were observed. Rats whose partners were exposed to one enriched environment for 31 days showed significantly increased immobility time in the forced swimming test, and significantly decreased time spent in the center area in the open-field test. Further, rats whose partners were exposed to one enriched environment for 31 days showed lower BDNF levels in the mPFC and dorsal hippocampus, but not following partner exposure for 14 days. These results suggest that social comparisons exist in rats and can induce psychosocial stress and other negative affect. This model will not only provide the possibility to reveal the neurobiological basis of the emotional impact of social comparison, but could also be used to confirm the conservative evolutionary characteristics of social comparison as a behavioral attribute.
收录类别SCI
WOS关键词STRESS-INDUCED HYPERTHERMIA ; MODEL
资助项目Chinese National Programs for Brain Science and Brain-like Intelligence Technology[2021ZD0202104] ; National Natural Science Foundation of China[31871111] ; Youth Innovation Promotion Association CAS[2020088] ; Key Laboratory of Mental Health, Institute of Psychology, CAS
WOS研究方向Behavioral Sciences ; Zoology
语种英语
出版者SPRINGER HEIDELBERG
WOS记录号WOS:001003118900001
资助机构Chinese National Programs for Brain Science and Brain-like Intelligence Technology ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Key Laboratory of Mental Health, Institute of Psychology, CAS
源URL[http://ir.psych.ac.cn/handle/311026/45488]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang, Jian-Jun
作者单位1.CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
2.Shanxi Univ Chinese Med, Natl Int Joint Res Ctr Mol Chinese Med, Shanxi Key Lab Chinese Med Encephalopathy, Jinzhong, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Xue, Bing,Ma, Yin-Yan,Zhu, Jie-Ying,et al. Chronic social comparison elicits depression- and anxiety-like behaviors and alterations in brain-derived neurotrophic factor expression in male rats[J]. ANIMAL COGNITION,2023:15.
APA Xue, Bing.,Ma, Yin-Yan.,Zhu, Jie-Ying.,Mu, Yan.,Li, Yong-Hui.,...&Zhang, Jian-Jun.(2023).Chronic social comparison elicits depression- and anxiety-like behaviors and alterations in brain-derived neurotrophic factor expression in male rats.ANIMAL COGNITION,15.
MLA Xue, Bing,et al."Chronic social comparison elicits depression- and anxiety-like behaviors and alterations in brain-derived neurotrophic factor expression in male rats".ANIMAL COGNITION (2023):15.

入库方式： OAI收割

来源：心理研究所

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