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Dynamic evolution of the anterior cingulate-insula network during seizures

文献类型：期刊论文

作者Yang, Yujiao1; Chen, Dong2; Wang, Jing1; Wang, Jie3; Yan, Zhaofen1; Deng, Qinqin1; Zhang, Liping1; Luan, Guoming4,5,6,8; Wang, Mengyang1,7; Li, Tianfu1,5,6,7
刊名CNS NEUROSCIENCE & THERAPEUTICS
出版日期2023-06-12
页码12
ISSN号1755-5930
关键词anterior cingulate cortex epilepsy excitation-inhibition ratio functional connectivity insula
DOI10.1111/cns.14310
通讯作者Luan, Guoming(luangm@ccmu.edu.cn) ; Wang, Mengyang(mengyangwang@ccmu.edu.cn) ; Li, Tianfu(tianfuli@ccmu.edu.cn)
英文摘要ObjectivesIn physiological situations, the anterior cingulate cortex (ACC) and anterior insular cortex (AIC) are prone to coactivation. The functional connectivity and interaction between ACC and AIC in the context of epilepsy remain unclear. This study aimed to investigate the dynamic coupling between these two brain regions during seizures. MethodsPatients who underwent stereoelectroencephalography (SEEG) recording were included in this study. The SEEG data were visually inspected and quantitatively analyzed. The narrowband oscillations and aperiodic components at seizure onset were parameterized. The frequency-specific non-linear correlation analysis was applied to the functional connectivity. The excitation/inhibition ratio (E:I ratio) reflected by the aperiodic slope was performed to evaluate the excitability. ResultsTwenty patients were included in the study, with 10 diagnosed with anterior cingulate epilepsy and 10 with anterior insular epilepsy. In both types of epilepsy, the correlation coefficient (h(2)) between the ACC and AIC at seizure onset exhibited a significantly higher value than that during interictal and preictal periods (p < 0.05). The direction index (D) showed a significant increase at seizure onset, serving as an indicator for the direction of information flow between these two brain regions with up to 90% accuracy. The E:I ratio increased significantly at seizure onset, with the seizure-onset zone (SOZ) demonstrating a more pronounced increase compared to non-SOZ (p < 0.05). For seizures originating from AIC, the E:I ratio was significantly higher in the AIC than in the ACC (p = 0.0364). ConclusionsIn the context of epilepsy, the ACC and AIC are dynamically coupled during seizures. The functional connectivity and excitability exhibit a significant increase at seizure onset. By analyzing connectivity and excitability, the SOZ in ACC and AIC can be identified. The direction index (D) serves as an indicator for the direction of information flow from SOZ to non-SOZ. Notably, the excitability of SOZ changes more significantly than that of non-SOZ.
收录类别SCI
WOS关键词OLD-WORLD MONKEY ; LOBE ; EXCITATION ; EPILEPSY ; INHIBITION ; BALANCE ; SIGNALS ; IMPACT ; CORTEX ; FEEL
资助项目China Association Against Epilepsy Research Fund ; Hygiene and Health Development Scientific Research Fostering Plan of Haidian District Beijing[HP2021 50801] ; Sanbo Brain Hospital, Capital Medical University ; STI2030 Major Projects[2022ZD0205000]
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy
语种英语
出版者WILEY
WOS记录号WOS:001004771300001
资助机构China Association Against Epilepsy Research Fund ; Hygiene and Health Development Scientific Research Fostering Plan of Haidian District Beijing ; Sanbo Brain Hospital, Capital Medical University ; STI2030 Major Projects
源URL[http://ir.psych.ac.cn/handle/311026/45552]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Luan, Guoming; Wang, Mengyang; Li, Tianfu
作者单位1.Capital Med Univ, Sanbo Brain Hosp, Dept Neurol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
3.Capital Inst Pediat, Dept Electrophysiol, Beijing, Peoples R China
4.Capital Med Univ, Sanbo Brain Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
5.Capital Med Univ, Sanbo Brain Hosp, Beijing Key Lab Epilepsy, Beijing, Peoples R China
6.Capital Med Univ, Beijing Inst Brain Disorders, Beijing, Peoples R China
7.Capital Med Univ, Sanbo Brain Hosp, Dept Neurol, 50 Xiang Shan Yi Ke Song Rd, Beijing, Peoples R China
8.Capital Med Univ, Sanbo Brain Hosp, Beijing Key Lab Epilepsy, 50 Xiang Shan Yi Ke Song Rd, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Yujiao,Chen, Dong,Wang, Jing,et al. Dynamic evolution of the anterior cingulate-insula network during seizures[J]. CNS NEUROSCIENCE & THERAPEUTICS,2023:12.
APA Yang, Yujiao.,Chen, Dong.,Wang, Jing.,Wang, Jie.,Yan, Zhaofen.,...&Li, Tianfu.(2023).Dynamic evolution of the anterior cingulate-insula network during seizures.CNS NEUROSCIENCE & THERAPEUTICS,12.
MLA Yang, Yujiao,et al."Dynamic evolution of the anterior cingulate-insula network during seizures".CNS NEUROSCIENCE & THERAPEUTICS (2023):12.

入库方式： OAI收割

来源：心理研究所

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