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Motor cortical plasticity as a predictor of treatment response to high frequency repetitive transcranial magnetic stimulation (rTMS) for cognitive function in drug-naive patients with major depressive disorder

文献类型：期刊论文

作者Li, Xingxing1; Yu, Chang1; Ding, Yan1; Chen, Zan1; Zhuang, Wenhao1; Liu, Zhiwang1; Fan, Jialin2; Yan, Hui3; Xu, Weiqian3; Zhu, Guidong2
刊名JOURNAL OF AFFECTIVE DISORDERS
出版日期2023-08-01
卷号334页码:180-186
关键词Depression Cortical plasticity Cognitive rTMS
ISSN号0165-0327
DOI10.1016/j.jad.2023.04.085
通讯作者Xu, Weiqian(zjttxwq@163.com) ; Zhu, Guidong(hzzcer@126.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn) ; Zhou, Dongsheng(wyzhouds@sina.com)
英文摘要Background: There is growing evidence that repetitive transcranial magnetic stimulation (rTMS) can improve cognitive function in patients with major depressive disorder (MDD). Few biomarkers are currently available to predict cognitive response in MDD patients. This study aimed to examine whether cortical plasticity played an important role in improving cognitive deficits in MDD patients treated with rTMS.Methods: A total of 66 MDD patients and 53 healthy controls were recruited. MDD patients were randomly assigned to receive 10 Hz active or sham rTMS 5 days per week for 4 weeks. Cognitive function was assessed using the Repeatable Battery for assessing Neuropsychological Status (RBANS), while depressive symptoms were assessed with the Hamilton Rating Scale for Depression (HRSD-24) before and after treatment. We combined transcranial magnetic stimulation and muscle surface electrophysiological recording to measure plasticity in motor cortex areas in healthy controls at baseline and MDD patients before and after treatment. Results: Compared with healthy controls, cortical plasticity was impaired in MDD patients. Moreover, cortical plasticity was correlated with RBANS total score at baseline in MDD patients. After 4-week 10 Hz rTMS treat-ment, the impaired cortical plasticity was restored to some extent. Interestingly, 10 Hz rTMS treatment produced effective therapeutic effects on immediate memory, attention, and RBANS total score. Pearson correlation analysis shows that improvements in plasticity were positively correlated with improvement of immediate memory and RBANS total score. Conclusions: Our results show for the first time that 10 Hz rTMS can effectively treat impaired cortical plasticity and cognitive impairment in MDD patients and that changes in plasticity and cognitive function are closely related, which may indicate that motor cortical plasticity may play a vital role in cognitive impairment and that cortical plasticity may serve as a potential predictive biomarker for cognitive improvement in MDD patients.
收录类别SCI
WOS关键词PREFRONTAL CORTEX ; DOUBLE-BLIND ; BRAIN ; METAANALYSIS ; MECHANISMS ; EFFICACY ; STRESS
资助项目Basic Public Welfare Project of Zhejiang Province[LGF22H090055] ; Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission[2019RC079] ; Ningbo Medical and Health Brand Discipline[PPXK2018-08] ; Ningbo Natural Science Foundation of China[202003N4263] ; Ningbo Natural Science Foundation of China[2021J275] ; Ningbo Natural Science Foundation of China[2019A610298] ; Ningbo Medical & Health Leading Academic Discipline Project[2022-F28] ; Ningbo Medical Science and Technology Project[2019Y24] ; Ningbo Medical Science and Technology Project[2020Y19] ; Lishui Public Welfare Technology Application Research Project[2022GYX46] ; Ningbo Top Medical and Health Research Program[2022030410]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:001004233700001
出版者ELSEVIER
资助机构Basic Public Welfare Project of Zhejiang Province ; Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission ; Ningbo Medical and Health Brand Discipline ; Ningbo Natural Science Foundation of China ; Ningbo Medical & Health Leading Academic Discipline Project ; Ningbo Medical Science and Technology Project ; Lishui Public Welfare Technology Application Research Project ; Ningbo Top Medical and Health Research Program
源URL[http://ir.psych.ac.cn/handle/311026/45559]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Xu, Weiqian; Zhu, Guidong; Zhang, Xiangyang; Zhou, Dongsheng
作者单位1.Ningbo Kangning Hosp, Ningbo, Zhejiang, Peoples R China
2.Second Peoples Hosp Lishui, Lishui, Zhejiang, Peoples R China
3.Taizhou Second Peoples Hosp, Taizhou, Zhejiang, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
7.Ningbo Kangning Hosp, Ningbo Key Lab Sleep Med, Ningbo, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Li, Xingxing,Yu, Chang,Ding, Yan,et al. Motor cortical plasticity as a predictor of treatment response to high frequency repetitive transcranial magnetic stimulation (rTMS) for cognitive function in drug-naive patients with major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2023,334:180-186.
APA Li, Xingxing.,Yu, Chang.,Ding, Yan.,Chen, Zan.,Zhuang, Wenhao.,...&Zhou, Dongsheng.(2023).Motor cortical plasticity as a predictor of treatment response to high frequency repetitive transcranial magnetic stimulation (rTMS) for cognitive function in drug-naive patients with major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,334,180-186.
MLA Li, Xingxing,et al."Motor cortical plasticity as a predictor of treatment response to high frequency repetitive transcranial magnetic stimulation (rTMS) for cognitive function in drug-naive patients with major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 334(2023):180-186.

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来源：心理研究所

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