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11-Ethoxyviburtinal improves chronic restraint stress-induced anxiety-like behaviors in gender-specific mice via PI3K/Akt and E-2/ER beta signaling pathways

文献类型：期刊论文

作者Lyu, Yan1; Wei, Xiaojia1; Yang, Xue1; Li, Jiayuan1; Wan, Guohui1; Wang, Yuqing1; Hao, Zhuangzhuang1; Lu, Yifan1; Guo, Jianyou2; Shi, Jinli1,3
刊名PHYTOTHERAPY RESEARCH
出版日期2023-06-09
页码17
ISSN号0951-418X
关键词11-ethoxyviburtinal antagonists anxiety disorder estrogen receptor beta PI3K-Akt signaling pathway the male and female mice
DOI10.1002/ptr.7876
通讯作者Shi, Jinli(shijl@vip.sina.com)
英文摘要Anxiety disorder is a chronic and disabling psychiatric disorder that is more prevalent in females than in males. 11-Ethoxyviburtinal is an iridoid extracted from Valeriana jatamansi Jones, which has anxiolytic potential. The aim of the present work was to study the anxiolytic efficacy and mechanism of 11-ethoxyviburtinal in gender-specific mice. We first evaluated the anxiolytic-like efficacy of 11-ethoxyviburtinal in chronic restraint stress (CRS) mice of different sexes through behavioral experiments and biochemical indexes. In addition, network pharmacology and molecular docking were used to predict potential targets and important pathways for the treatment of anxiety disorder with 11-ethoxyviburtinal. Finally, the influence of 11-ethoxyviburtinal on phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt) signaling pathway, estrogen receptor beta (ER beta) expression, and anxiety-like behavior in mice was verified by western blotting, immunohistochemistry staining, antagonist intervention methods, and behavioral experiments. 11-ethoxyviburtinal alleviated the anxiety-like behaviors induced by CRS and inhibited neurotransmitter dysregulation and HPA axis hyperactivity. It inhibited the abnormal activation of the PI3K/Akt signaling pathway, modulated estrogen production, and promoted ER beta expression in mice. In addition, the female mice may be more sensitive to the pharmacological effects of 11-ethoxyviburtinal. 11-ethoxyviburtinal may exert its anxiolytic-like effects through PI3K/Akt and E2/ER beta signaling pathways. Meanwhile, by comparing the male and female mice, gender differences may affect the therapy and development of anxiety disorder.
收录类别SCI
WOS关键词NETWORK PHARMACOLOGY ; DISORDERS ; ESTROGEN ; HIPPOCAMPUS ; FEMALE ; DEPRESSION ; EXPLORATION ; INVOLVEMENT ; MODULATION ; ACTIVATION
资助项目National Natural Science Foundation of China[82073971] ; National Science and Technology Major Special Project[2020071720300]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者WILEY
WOS记录号WOS:001005219600001
资助机构National Natural Science Foundation of China ; National Science and Technology Major Special Project
源URL[http://ir.psych.ac.cn/handle/311026/45568]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Shi, Jinli
作者单位1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China
推荐引用方式
GB/T 7714		 Lyu, Yan,Wei, Xiaojia,Yang, Xue,et al. 11-Ethoxyviburtinal improves chronic restraint stress-induced anxiety-like behaviors in gender-specific mice via PI3K/Akt and E-2/ER beta signaling pathways[J]. PHYTOTHERAPY RESEARCH,2023:17.
APA Lyu, Yan.,Wei, Xiaojia.,Yang, Xue.,Li, Jiayuan.,Wan, Guohui.,...&Shi, Jinli.(2023).11-Ethoxyviburtinal improves chronic restraint stress-induced anxiety-like behaviors in gender-specific mice via PI3K/Akt and E-2/ER beta signaling pathways.PHYTOTHERAPY RESEARCH,17.
MLA Lyu, Yan,et al."11-Ethoxyviburtinal improves chronic restraint stress-induced anxiety-like behaviors in gender-specific mice via PI3K/Akt and E-2/ER beta signaling pathways".PHYTOTHERAPY RESEARCH (2023):17.

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来源：心理研究所

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