Neural correlates of mental time travel in individuals with high level of schizotypy
文献类型：期刊论文
| 作者 | Ye, Jun-yan1,2; Qin, Xiao-jing1,2,3; Cui, Ji-Fang4; Shi, Hai-song5; Liu, Jia-Li1,2; Huang, Jia1,2 ; Wang, Yi1,2; Yang, Tian-Xiao1,2; Lui, Simon S. Y.6; Wang, Ya1,2,7
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| 刊名 | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
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| 出版日期 | 2023-06-08 |
| 卷号 | 124页码:8 |
| 关键词 | Mental time travel Schizotypy Autobiographical memory Episodic future thinking Neural correlates |
| ISSN号 | 0278-5846 |
| DOI | 10.1016/j.pnpbp.2023.110734 |
| 通讯作者 | Wang, Ya(wangya@psych.ac.cn) |
| 英文摘要 | Background: Mental time travel (MTT) is the ability to re-experience past events (autobiographic memory, AM) and pre-experience possible future events (episodic future thinking, EFT) through mental simulation. Empirical findings suggest that individuals with high level of schizotypy exhibit MTT impairment. However, the neural correlates of this impairment remain unclear.Method: Thirty-eight individuals with high level of schizotypy and 35 low level of schizotypy were recruited to complete an MTT imaging paradigm. Participants were required to recall past events (AM condition), imagine possible future events (EFT condition) related to cue words, or generate exemplars related to category words (control condition) while undergoing functional Magnetic Resonance Imaging (fMRI).Results: AM showed greater activation in precuneus, bilateral posterior cingulate cortex, thalamus, and middle frontal gyrus than EFT. Individuals with high level of schizotypy exhibited reduced activation in the left anterior cingulate cortex during AM (vs. Control) and in the medial frontal gyrus during EFT (vs. Control) compared to individuals with low level of schizotypy. Although psychophysiological interaction analyses did not show any significant group difference, individuals with high level of schizotypy exhibited functional connectivity between left anterior cingulate cortex (seed) and right thalamus, between medial frontal gyrus (seed) and left cerebellum during MTT, whereas individuals with low level of schizotypy did not exhibit these functional connectivities. Conclusion: These findings suggest that decreased brain activations may underlie MTT deficits in individuals with high level of schizotypy. |
| 收录类别 | SCI |
| WOS关键词 | EPISODIC FUTURE THINKING ; AUTOBIOGRAPHICAL MEMORY ; SCHIZOPHRENIA ; METAANALYSIS ; PROSPECTION ; VALIDATION ; MECHANISMS ; SIMULATION ; PSYCHOSIS |
| 资助项目 | National Science Foundation of China[32071062] ; Philip KH Wong Foundation |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:001006837500001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 资助机构 | National Science Foundation of China ; Philip KH Wong Foundation |
| 源URL | [http://ir.psych.ac.cn/handle/311026/45578]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Wang, Ya |
| 作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Guangxi Med Univ, Nanning, Peoples R China 4.Natl Inst Educ Sci, Res Ctr Informat & Stat, Beijing, Peoples R China 5.North China Elect Power Univ, Mental Hlth Educ Ctr, Beijing, Peoples R China 6.Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China 7.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Jun-yan,Qin, Xiao-jing,Cui, Ji-Fang,et al. Neural correlates of mental time travel in individuals with high level of schizotypy[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2023,124:8. |
| APA | Ye, Jun-yan.,Qin, Xiao-jing.,Cui, Ji-Fang.,Shi, Hai-song.,Liu, Jia-Li.,...&Chan, Raymond C. K..(2023).Neural correlates of mental time travel in individuals with high level of schizotypy.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,124,8. |
| MLA | Ye, Jun-yan,et al."Neural correlates of mental time travel in individuals with high level of schizotypy".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 124(2023):8. |
入库方式： OAI收割
来源：心理研究所
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