Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-kappa B/ NLRP3 pathway and apoptosis
文献类型：期刊论文
| 作者 | Mokhtari, Tahmineh1,2 ; Yue, Lu-Peng1,2; Hu, Li1,2
|
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2023-02-06 |
| 卷号 | 13期号:1页码:15 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-023-28418-1 |
| 通讯作者 | Yue, Lu-Peng(yuelp@psych.ac.cn) ; Hu, Li(huli@psych.ac.cn) |
| 英文摘要 | In this study, we aimed to evaluate the anti-inflammatory and anti-apoptotic effects of melatonin (MLT) on neuropathic pain (NP)-induced anxiety and depression in a rat model. Adult male rats were separated into four groups, i.e., Sham-VEH: healthy animals received a vehicle, Sham-MLT (10 mg/kg), and chronic constrictive injury (CCI)-VEH: nerve ligation received the vehicle, and CCI-MLT. Next, we used behavioral tests to evaluate pain severity, anxiety, and depression. Finally, rats were sacrificed for molecular and histopathological studies. Behavioral tests showed that NP could induce depressive- and anxiety-like behaviors. NP activated NF-kappa B/NLRP3 inflammasome pathways by upregulating NF-kappa B, NLRP3, ASC, active Caspase-1, also enhancing the concentrations of cytokines (IL-1 beta and IL-18) in the prefrontal cortex (PFC) and hippocampus (HC). NP upregulated Bax, downregulated Bcl2, and increased cell apoptosis in the HC and PFC. The rats treated with MLT eliminated the effects of NP, as the reduced pain severity, improved anxiety- and depressive-like behaviors, ameliorated NF-kappa B/NLRP3 inflammasome pathways, and modulated levels of cytokines in the HC and PFC. MLT could promote cell survival from apoptosis by modulating Bax and Bcl2. Therefore, it might be inferred that its anti-inflammatory and anti-apoptotic properties mediate the beneficial effects of MLT in NP-induced affective disorders. |
| 收录类别 | SCI |
| WOS关键词 | DEPRESSION-LIKE BEHAVIOR ; UP-REGULATION ; HIPPOCAMPAL ; STRESS ; INJURY ; INFLAMMASOME ; EXPRESSION ; MECHANISMS ; NEUROINFLAMMATION ; DYSFUNCTION |
| 资助项目 | National Natural Science Foundation of China[32000749] ; National Natural Science Foundation of China[32071061] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Science[E0CX491005] ; CAS-TWAS president's fellowship program |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | NATURE PORTFOLIO |
| WOS记录号 | WOS:000989985700028 |
| 资助机构 | National Natural Science Foundation of China ; Scientific Foundation of Institute of Psychology, Chinese Academy of Science ; CAS-TWAS president's fellowship program |
| 源URL | [http://ir.psych.ac.cn/handle/311026/45599]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Yue, Lu-Peng; Hu, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mokhtari, Tahmineh,Yue, Lu-Peng,Hu, Li. Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-kappa B/ NLRP3 pathway and apoptosis[J]. SCIENTIFIC REPORTS,2023,13(1):15. |
| APA | Mokhtari, Tahmineh,Yue, Lu-Peng,&Hu, Li.(2023).Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-kappa B/ NLRP3 pathway and apoptosis.SCIENTIFIC REPORTS,13(1),15. |
| MLA | Mokhtari, Tahmineh,et al."Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-kappa B/ NLRP3 pathway and apoptosis".SCIENTIFIC REPORTS 13.1(2023):15. |
入库方式： OAI收割
来源：心理研究所
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