Age of Onset Moderates the Association between Total Antioxidant Capacity and Cognitive Deficits in Patients with Drug-Naive Schizophrenia
文献类型：期刊论文
| 作者 | Li, Jiaxin1,2 ; Li, Deyang1,2; Guo, Junru3; Wang, Dongmei1,2; Zhang, Xiangyang1,2
|
| 刊名 | ANTIOXIDANTS
 |
| 出版日期 | 2023-06-01 |
| 卷号 | 12期号:6页码:12 |
| 关键词 | schizophrenia age of onset TAOC cognitive function oxidative stress |
| DOI | 10.3390/antiox12061259 |
| 通讯作者 | Wang, Dongmei(wangdm@psych.ac.cn) |
| 英文摘要 | Schizophrenia patients with an earlier age of onset have been found to have more serious negative symptoms and cognitive deficits. Oxidative stress is thought to be implicated in cognitive impairment in schizophrenia. Total antioxidant capacity (TAOC) is an essential indicator of oxidative stress. However, the association between age of onset, TAOC, and cognitive performance in schizophrenia remains unexplored. In this study, 201 patients (age: 26.5 & PLUSMN; 9.6 years; male: 53.2%) with drug-naive schizophrenia were recruited. Clinical symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS). Cognitive functioning was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Plasma TAOC levels were analyzed using established procedures. Results showed that early-onset (EO) patients had higher TAOC levels, more severe negative symptoms and performed worse on visuospatial/constructional, language and RBANS total scores than non-EO patients. After Bonferroni correction, only non-EO patients showed a significant inverse relationship between TAOC levels and RBANS language, attention, and total scores. Our findings suggest that an early/late age of onset may be correlated with psychopathological symptoms, cognitive impairment and oxidative responses in schizophrenia. Furthermore, the age of onset may moderate the relationship between TAOC and cognitive function in patients with schizophrenia. These findings suggest that improving oxidative stress status in non-EO schizophrenia patients may enhance their cognitive function. |
| 收录类别 | SCI |
| WOS关键词 | OXIDATIVE STRESS ; PARANOID SCHIZOPHRENIA ; NEGATIVE SYMPTOMS ; PERFORMANCE ; PREVALENCE ; PREDICTORS ; MODEL |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:001013868600001 |
| 出版者 | MDPI |
| 源URL | [http://ir.psych.ac.cn/handle/311026/45612]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Wang, Dongmei |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Guizhou Minzu Univ, Dept Psychol, Guiyang 550025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jiaxin,Li, Deyang,Guo, Junru,et al. Age of Onset Moderates the Association between Total Antioxidant Capacity and Cognitive Deficits in Patients with Drug-Naive Schizophrenia[J]. ANTIOXIDANTS,2023,12(6):12. |
| APA | Li, Jiaxin,Li, Deyang,Guo, Junru,Wang, Dongmei,&Zhang, Xiangyang.(2023).Age of Onset Moderates the Association between Total Antioxidant Capacity and Cognitive Deficits in Patients with Drug-Naive Schizophrenia.ANTIOXIDANTS,12(6),12. |
| MLA | Li, Jiaxin,et al."Age of Onset Moderates the Association between Total Antioxidant Capacity and Cognitive Deficits in Patients with Drug-Naive Schizophrenia".ANTIOXIDANTS 12.6(2023):12. |
入库方式： OAI收割
来源：心理研究所
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